Pirfenidone is a potent anti-fibrotic TGF-β inhibitor. It affects TGF-β/Smad, NF-κB, and Wnt/β-catenin signaling pathways by blocking Smad2/3 phosphorylation and modulating MAPK activation, effectively inhibiting fibroblast-to-myofibroblast differentiation and extracellular matrix production to attenuate fibrosis.
Pirfenidone IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Pirfenidone Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.