Paclitaxel: Mechanism of Action

Paclitaxel MOA:Targeting Microtubule/Apoptosis Pathway for Nanomedicine and Targeted Drug Delivery

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Paclitaxel is a potent, high-affinity β-tubulin stabilizer. It affects AKT/mTOR, MAPK, and PERK/eIF2α signaling by binding to β-tubulin to promote microtubule polymerization and prevent depolymerization, effectively promoting G2/M mitotic arrest, apoptosis, and immunogenic cell death.

Primary Applications and Mechanism of Action