Paclitaxel is a potent, high-affinity β-tubulin stabilizer. It affects AKT/mTOR, MAPK, and PERK/eIF2α signaling by binding to β-tubulin to promote microtubule polymerization and prevent depolymerization, effectively promoting G2/M mitotic arrest, apoptosis, and immunogenic cell death.
Paclitaxel IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Paclitaxel Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.
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