Nutlin-3a SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

Product Name: Nutlin-3a
Catalog Number: S8059
CAS Number: 675576-98-4
IUPAC Name: 2-Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-

Relevant identified uses and uses advised against

Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

Company : Selleck Chemicals
TollFree : +1 877 796-6397
Tel : +1 832 582-8158
Fax : +1 832 582-8590

Emergency telephone number

Emergency phone #: +1 832 582-8158

2. HAZARDS IDENTIFICATION

GHS Classification
This substance is not classified as a hazardous substance or mixture in accordance with the OSHA Hazard Communication Standard (29 CFR 1910.1200).

GHS Label Elements
The product is not a hazardous substance or mixture and does not require specific GHS label elements or pictograms.

Other Hazards
None known.

3. COMPOSITION/INFORMATION ON INGREDIENTS

Substance / Mixture: Substance
Components: No hazardous ingredients are present in this substance.

4. FIRST AID MEASURES

If Inhaled: Move the person to fresh air.
In Case of Skin Contact: Immediately remove all contaminated clothing. Rinse the skin with water or shower.
In Case of Eye Contact: Rinse thoroughly with plenty of water. Remove contact lenses if present.
If Swallowed: Have the victim drink a maximum of two glasses of water. Consult a physician if the individual feels unwell.
Most Important Symptoms and Effects: The most important known symptoms and effects are described in the labeling (Section 2) and/or Section 11.
Protection of First-Aiders: Refer to Section 8 for personal protective equipment.
Notes to Physician: N/A.

5. FIREFIGHTING MEASURES

Extinguishing Media: There are no limitations on extinguishing agents for this substance.
Hazardous Combustion Products: Carbon oxides, Nitrogen oxides (NOx), and Hydrogen chloride gas.
Specific Extinguishing Methods: Use water spray jet to suppress gases, vapors, or mists. Prevent fire extinguishing water from contaminating surface water or groundwater systems.
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus in the event of a fire.

6. ACCIDENTAL RELEASE MEASURES

Personal Precautions and Emergency Procedures: For non-emergency personnel, avoid inhalation of dusts and evacuate the danger area. For emergency responders, refer to personal protection measures in Section 8.
Environmental Precautions: Do not allow the product to enter drains.
Methods and Materials for Containment and Cleaning Up: Cover drains. Collect, bind, and pump off spills. Observe material restrictions as noted in Sections 7 and 10. Take up dry and dispose of properly. Clean the affected area and avoid the generation of dusts.

7. HANDLING AND STORAGE

Precautions for Safe Handling: Refer to Section 2.2 for precautions.
Conditions for Safe Storage: Keep the container tightly closed in a dry location.
Storage Class: 11 (Combustible Solids).
Recommended Storage Temperature: -4 °F / -20 °C.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Control Parameters: Contains no substances with occupational exposure limit values.
Engineering Measures: N/A.
Personal Protective Equipment:

Respiratory Protection: Required when dusts are generated. Recommended filter type P1 (DIN EN 143).
Hand Protection: Handle with impervious nitrile rubber gloves. Full and splash contact recommendations: 0.11 mm thickness, 480 min breakthrough time (e.g., KCL 741 Dermatril® L).
Eye Protection: Use safety glasses tested and approved under standards such as NIOSH (US) or EN 166 (EU).
Hygiene Measures: Change contaminated clothing and wash hands after handling the substance.

9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance: powder
Color: N/A
Odor: N/A
Odor Threshold: N/A
pH: N/A
Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Evaporation Rate: N/A
Flammability: N/A
Explosion Limits: N/A
Vapor Pressure/Density: N/A
Relative Density: N/A
Water Solubility: N/A
Partition Coefficient (n-octanol/water): N/A
Autoignition Temperature: N/A
Decomposition Temperature: N/A
Viscosity: N/A
Explosive/Oxidizing Properties: N/A
Molecular Weight: 581.49 g/mol

10. STABILITY AND REACTIVITY

Reactivity: N/A.
Chemical Stability: The product is chemically stable under standard ambient conditions (room temperature).
Possibility of Hazardous Reactions: N/A.
Conditions to Avoid: No information available.
Incompatible Materials: Strong oxidizing agents.
Hazardous Decomposition Products: In the event of fire, see Section 5.

11. TOXICOLOGICAL INFORMATION

Acute Toxicity: N/A for oral, inhalation, or dermal routes.
Skin Corrosion/Irritation: N/A.
Serious Eye Damage/Irritation: N/A.
Respiratory or Skin Sensitization: Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals.
Germ Cell Mutagenicity: N/A.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as a probable, possible, or confirmed human carcinogen by IARC, NTP, or OSHA.
Reproductive Toxicity: N/A.
STOT - Single/Repeated Exposure: N/A.
Aspiration Hazard: N/A.
Additional Information: To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

12. ECOLOGICAL INFORMATION

Ecotoxicity: N/A.
Persistence and Degradability: N/A.
Bioaccumulative Potential: N/A.
Mobility in Soil: N/A.
Other Adverse Effects: N/A.

13. DISPOSAL CONSIDERATIONS

Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers. Do not mix with other waste. Handle uncleaned containers as if they contained the product itself.

14. TRANSPORT INFORMATION

DOT (49 CFR): Not regulated as a dangerous good.
IMDG: Not regulated as a dangerous good.
IATA: Not regulated as a dangerous good.
Transport in Bulk: Not applicable for the product as supplied.
Special Precautions: Not classified as dangerous in the meaning of transport regulations. Poison Inhalation Hazard: No.

15. REGULATORY INFORMATION

CERCLA Reportable Quantity
This material does not contain any components with a CERCLA RQ.

SARA 304 Extremely Hazardous Substances Reportable Quantity
This material does not contain any components with a section 304 EHS RQ.

SARA 302 Extremely Hazardous Substances Threshold Planning Quantity
This material does not contain any components with a section 302 EHS TPQ.

SARA 311/312 Hazards
No SARA Hazards

SARA 313
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.

US State Regulations

Massachusetts Right To Know
No components are subject to the Massachusetts Right to Know Act.

Pennsylvania Right To Know
2-Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]- (CAS-No. 675576-98-4)

New Jersey Right To Know
2-Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]- (CAS-No. 675576-98-4)

California Prop. 65
This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.

The components of this product are reported in the following inventories:

TSCA list
No substances are subject to a Significant New Use Rule.
No substances are subject to TSCA 12(b) export notification requirements.

16. OTHER INFORMATION

Revision Date: 2026/06/30
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.