Nutlin-3a is a potent and selective MDM2 inhibitor. It affects p53 signaling by binding to the p53-binding pocket of MDM2 to disrupt the MDM2-p53 interaction, promoting p53 stabilization, cell cycle arrest, and apoptosis in cancer cells.
Nutlin-3a IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Nutlin-3a Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.