LB-100 is a selective catalytic PP2A inhibitor. It affects Wnt/β-catenin and mTORC1 signaling pathways, and by inhibiting PP2A enzymatic activity, it inhibits tumor proliferation and EMT, and promotes immune cell activation.
LB-100 MOA:Targeting PP2A/PD-1 Pathway for Cancer Immunotherapy Combination
LB-100 is a selective catalytic PP2A inhibitor. It affects Wnt/β-catenin and mTORC1 signaling pathways, and by inhibiting PP2A enzymatic activity, it inhibits tumor proliferation and EMT, and promotes immune cell activation.