CAS No. 1632032-53-1
Batch:
Purity:99.91
Chemical Structure
Check the
LB-100
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1R,4S)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid | |
|---|---|---|
| CAS Number | 1632032-53-1 | |
| Molecular Formula |
C13H20N2O4 |
|
| Molecular Weight (MW) | 268.31 | |
| SMILES | CN1CCN(CC1)C(=O)C2C3CCC(C2C(=O)O)O3 | |
| InChIKey | JUQMLSGOTNKJKI-IZUQBHJASA-N |
LB-100 is a water-soluble protein phosphatase 2A (PP2A) inhibitor that demonstrates antiproliferative activity in BxPc-3 (IC50 = and Panc-1 (IC50 = cells. Inhibition of PP2A by LB-100 disrupts intracellular phosphorylation cascades, triggering cell cycle arrest at the G2/M phase. Downstream, this block impairs DNA damage repair pathways and induces apoptosis, thereby sensitizing tumor cells to cytotoxic therapy. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 54 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 54 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 53 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- LB-100 Mechanism of Action: PP2A Inhibition in Tumor Cell Research
- LB-100 Clinical Trials
- LB-100 Working Concentration | Cell Culture | Treatment
- LB-100 Solubility in DMSO
- LB-100 Stock Solution
- LB-100 Storage
- LB-100 Stability
- LB-100 Combination Database
- LB-100 Molecular Weight
- LB-100 SMILES
- LB-100 Chemical Structure (2D and 3D)
- LB-100 IC50 for Cell-based and Cell-free Assays
- LB-100 Sigma (XPIH9BCF735D)? Try a better option.
- LB-100 MedChemExpress (HY-18597)? Try a better option.
- LB-100 Cayman (29105)? Try a better option.
- LB-100 APExBIO (B4846)? Try a better option.
- LB-100 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.