Capmatinib (INC280): Selectivity & Specificity

Capmatinib (INC280) is a potent inhibitor of c-Met kinase (0.13 nM), MET (0.13 nM), P-gp (12.0 μM), and BCRP (16.4 μM). Capmatinib (INC280) exhibits the greatest inhibitory potency toward MET (IC50 = 0.13 nM).