CAS No. 1029712-80-8
Batch:
Purity:99.99
Chemical Structure
Check the
Capmatinib (INC280)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide | |
|---|---|---|
| CAS Number | 1029712-80-8 | |
| Molecular Formula |
C23H17FN6O |
|
| Molecular Weight (MW) | 412.42 | |
| SMILES | CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F | |
| InChIKey | LIOLIMKSCNQPLV-UHFFFAOYSA-N |
Capmatinib (INCB28060) is an ATP-competitive c-MET inhibitor with an IC50 of. It demonstrates high specificity for c-MET over other human kinases, potently blocking c-MET autophosphorylation and activation of downstream effectors. Downstream suppression of Wnt/β-catenin and EMT signaling pathways inhibits c-MET-dependent cell proliferation and migration while effectively inducing apoptosis and suppressing tumor growth in c-MET-driven models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
6 mg/mL
(14.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
6 mg/mL
(14.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
6 mg/mL
(14.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
14 mg/mL
(33.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
1.87 mg/mL
(4.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Capmatinib (INC280) Mechanism of Action: MET Inhibition in Non-Small Cell Lung Cancer Cells Research
- Capmatinib (INC280) Clinical Trials
- Capmatinib (INC280): Selectivity & Specificity
- Capmatinib (INC280) Working Concentration | Cell Culture | Treatment
- Capmatinib (INC280) Solubility in DMSO
- Capmatinib (INC280) Stock Solution
- Capmatinib (INC280) Storage
- Capmatinib (INC280) Stability
- Capmatinib (INC280) Combination Database
- Capmatinib (INC280) Molecular Weight
- Capmatinib (INC280) SMILES
- Capmatinib (INC280) Chemical Structure (2D and 3D)
- Capmatinib (INC280) IC50 for Cell-based and Cell-free Assays
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- Capmatinib (INC280) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.