Cell-free Assays (IC50/Ki) for Capmatinib (INC280)

Key TargetIC50 (Cell-free)DescriptionReference
c-Met kinase 0.13 nM In vitro kinase assay PMC5873445
MET 0.13 nM cell-free assay PMC7373856
P-gp, BCRP 12.0 μM (P-gp), 16.4 μM (BCRP) In vitro assay PMC8359310
MET 0.13 nM biochemical assay PMC9720758

Cell-based Assay (IC50) for Capmatinib (INC280)

Cell TypeIC50 (Cell-based)DescriptionReference
BxPC3 indeterminate Cell viability studies, non-linear fit variable slope four parameters, bottom=0, with Graphpad Prism. Download PDF
Capan 2 indeterminate Cell viability studies, non-linear fit variable slope four parameters, bottom=0, with Graphpad Prism. Download PDF
Suit 2 indeterminate Cell viability studies, non-linear fit variable slope four parameters, bottom=0, with Graphpad Prism. Download PDF
MIA PaCa-2 indeterminate Cell viability studies, non-linear fit variable slope four parameters, bottom=0, with Graphpad Prism. Download PDF
MPE primary cells 6.5 nM 3D tumorsphere model, CCK-8 assay Download PDF
Check the Capmatinib (INC280) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

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