ICG-001: Selectivity & Specificity

ICG-001 is a potent inhibitor of CREBBP (~1 nM), WNT/β-catenin signaling (10 nM), CTNNB1/TCF, CTNNB1, REN, SNAI1, ACTA2, Collagen IV, FN1, Collagen I, Collagen III, SERPINE1, S100A4, SNAI2, CD3, CD68, BIRC5, WNT3A, LRP6, WNT10B, PDGFRB, VIM, HSC migration (5000 nM), POSTN, AXIN2, HOXB9, CTNNB1/FOXO1 interaction, WNT/β-catenin/CBP signaling. ICG-001 exhibits the greatest inhibitory potency toward CREBBP (IC50 = ~1 nM).