GSK3326595 (Pemrametostat, EPZ015938): Mechanism of Action

GSK3326595 (Pemrametostat, EPZ015938) MOA:Targeting PRMT5/p53 Pathway for Solid Tumors

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GSK3326595 (Pemrametostat) is a potent PRMT5 inhibitor. It affects PI3K/AKT and HIF-1α/VEGF signaling by reducing symmetric dimethylarginine (SDMA) levels and inducing DNA damage, effectively inhibiting tumor cell proliferation and angiogenesis.

Primary Applications and Mechanism of Action