CAS No. 1616392-22-3

Batch: Purity:99.85
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GSK3326595 (Pemrametostat, EPZ015938) Chemical Structure
Chemical Structure
Check the GSK3326595 (Pemrametostat, EPZ015938) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide
CAS Number 1616392-22-3
Molecular Formula

C24H32N6O3
Molecular Weight (MW) 452.55
SMILES CC(=O)N1CCC(CC1)NC2=NC=NC(=C2)C(=O)NCC(CN3CCC4=CC=CC=C4C3)O
InChIKey JLCCNYVTIWRPIZ-NRFANRHFSA-N

Ordering Information

Biological Activity

Pemrametostat (GSK3326595, EPZ015938) is an orally active, potent, and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). Pharmacological inhibition of PRMT5 suppresses symmetric dimethylation of arginine residues on histones and non-histone substrates, disrupting downstream transcriptional regulation and RNA splicing. This targeted inhibition impairs tumor cell proliferation and induces robust antitumor growth inhibition in preclinical animal models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 91 mg/mL (201.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 32 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.