GSK3326595 (Pemrametostat) is a potent PRMT5 inhibitor. It affects PI3K/AKT and HIF-1α/VEGF signaling by reducing symmetric dimethylarginine (SDMA) levels and inducing DNA damage, effectively inhibiting tumor cell proliferation and angiogenesis.
Comprehensive IC50 Values for GSK3326595 (Pemrametostat, EPZ015938) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.
GSK3326595 (Pemrametostat) is a potent PRMT5 inhibitor. It affects PI3K/AKT and HIF-1α/VEGF signaling by reducing symmetric dimethylarginine (SDMA) levels and inducing DNA damage, effectively inhibiting tumor cell proliferation and angiogenesis.