Clinical Trials

Numerous clinical trials evaluate the therapeutic utility of glucosamine across diverse conditions, primarily focusing on knee osteoarthritis and joint pain, alongside periodontal pockets, irritable bowel syndrome, hypercholesterolemia, and breast neoplasms. Spanning Early Phase 1 through Phase 4 trials as well as non-interventional studies, these protocols display recruitment statuses ranging from actively recruiting and completed to terminated. Research is funded by various entities, including academic institutions, cancer research centers, and commercial sponsors.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07225998 NOT_YET_RECRUITING
Crohns Disease
Johns Hopkins University
 2026-06-30 PHASE2
NCT07119645 RECRUITING
Activity-Related Knee Discomfort; Joint Discomfort; Functional Joint Pain; Functional Knee Pain; Knee Acute and Chronic Pain
Hofseth Biocare ASA
 2025-01-20
NCT06917287 ACTIVE_NOT_RECRUITING
Knee Osteoarthritis (OA)
Vedic Lifesciences Pvt. Ltd.
 2025-04-20
NCT07717957 COMPLETED
Knee Osteoarthritis
BREGO Life Sciences
 2024-07-01
NCT07746466 COMPLETED
Knee Osteoarthritis (Kellgren-Lawrence Grade 1-3)
Liaquat National Hospital & Medical College
 2023-06-01
NCT07114016 COMPLETED
Oral Lichen Planus
Future University in Egypt
 2023-05-01 PHASE4
NCT06971484 COMPLETED
Bioavailability and Pharmacokinetics
Isura
 2025-01-06
NCT06578663 COMPLETED
Osteoarthritis of Knee
Horus University
 2024-06-01
NCT06581094 COMPLETED
Inflammation; Knee Pain Chronic
Taipei Medical University
 2024-08-20
NCT06798428 COMPLETED
Grade I and II Knee Meniscal Injuries
Eslam Elsayed Ali Shohda
 2022-10-01
NCT04994561 WITHDRAWN
Aging
Vitality in Aging Research Group, Inc.
 2022-06 PHASE1
NCT05212259 UNKNOWN
Joint Pain
Vedic Lifesciences Pvt. Ltd.
 2022-10-10
NCT05474586 COMPLETED
Osteoarthritis, Knee
Vedic Lifesciences Pvt. Ltd.
 2022-08-08
NCT06200415 COMPLETED
Periodontal Pocket
Ain Shams University
 2022-11-08 PHASE2
NCT05699473 TERMINATED
Healthy
Lesaffre International
 2023-01-12
NCT06268483 COMPLETED
Urinary Tract Infections, Recurrent
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
 2022-03-01
NCT06200415 Completed
Periodontal Pocket
Ain Shams University
 2022-11-08 Phase 2
NCT05420441 UNKNOWN
Knee Osteoarthritis; Knee Arthritis
October 6 University
 2022-04-25
NCT05038436 COMPLETED
Cholesterol Lowering
Certmedica International GmbH
 2021-09-16
NCT05305937 Not yet recruiting
Malignant Tumor of Breast|Benign Breast Lumps|High-Risk Breast Cancer
Meir Medical Center|Tel Aviv University
 2022-05 Not Applicable
NCT05321836 COMPLETED
Knee Osteoarthritis
Muhammad salman, PT
 2021-07-26
NCT05038436 Completed
Cholesterol Lowering
Certmedica International GmbH|University Hospital Bonn
 2021-09-16 Not Applicable
NCT03716115 COMPLETED
Severe Acute Malnutrition
Queen Mary University of London
 2020-05-04 PHASE2
NCT04470336 COMPLETED
Knee Osteoarthritis
Vedic Lifesciences Pvt. Ltd.
 2020-07-09
NCT03936192 WITHDRAWN
Knee Osteoarthritis
Eurofarma Laboratorios S.A.
 2019-01 PHASE3
NCT04706416 COMPLETED
Coronavirus; Covid19
Quantinosis.ai LLC
 2020-11-14 PHASE1
NCT04665804 COMPLETED
Knee Osteoarthritis
Foundation University Islamabad
 2020-06-10
NCT04654871 COMPLETED
Osteoarthritis; Osteoarthritis, Knee
Foundation University Islamabad
 2020-01-01
NCT02882438 UNKNOWN
Foot Infection Tinea Pedis
Ahmed A. H. Abdellatif
 2016-01 PHASE1
NCT02830919 COMPLETED
Osteoarthritis of Knee
Eurofarma Laboratorios S.A.
 2016-12-05 PHASE3
NCT03963323 COMPLETED
Healthy Subject
Fred Hutchinson Cancer Center
 2018-05-11 PHASE1
NCT03913052 UNKNOWN
Knee Osteoarthritis
Istanbul Bilgi University
 2018-11-02
NCT03827161 COMPLETED
Healthy Subject; Overweight
Fred Hutchinson Cancer Center
 2017-08-01 PHASE1
NCT03717714 COMPLETED
Osteoarthritis of the Knee
Vietstar Biomedical Research
 2017-04-01
NCT02178137 COMPLETED
Osteo Arthritis of the Knees
Indus Hospital and Health Network
 2014-06 PHASE4
NCT03106584 UNKNOWN
Knee Osteoarthritis
University College Dublin
 2017-05-01
NCT03827161 Completed
Healthy Subject|Overweight
Fred Hutchinson Cancer Center
 2017-08-01 Phase 1
NCT02604381 COMPLETED
Osteoarthritis of the Knee
KGK Science Inc.
 2015-11 PHASE2
NCT01074476 UNKNOWN
Knee Osteoarthritis
University of British Columbia
 2015-06
NCT02823548 UNKNOWN
Hand Osteoarthritis
Bioiberica
 2016-08 PHASE4
NCT03743896 COMPLETED
Osteoarthritis, Knee
Lynk Biotechnologies Pte Ltd
 2016-05-18 PHASE4
NCT02511041 TERMINATED
PGM3
National Institute of Allergy and Infectious Diseases (NIAID)
 2015-06-30 PHASE1
NCT01893606 UNKNOWN
Irritable Bowel Syndrome
Third Military Medical University
 2013-04 PHASE2; PHASE3
NCT02504060 UNKNOWN
Irritable Bowel Syndrome
Third Military Medical University
 2015-06 PHASE3
NCT02682277 COMPLETED
Obesity
Certmedica International GmbH
 2014-05
NCT02858297 COMPLETED
Oral Lichen Planus
Ain Shams University
 2015-05 PHASE4
NCT02448199 UNKNOWN
Osteoarthritis
Zodiac Produtos Farmaceuticos S.A.
 2015-07 PHASE3
NCT03743896 Completed
Osteoarthritis Knee
Lynk Biotechnologies Pte Ltd|T&T Family Health Clinic and Surgery Singapore|Temasek Polytechnic School of Applied Science Singapore
 2016-05-18 Phase 4
NCT02167516 COMPLETED
Knee Osteoarthritis
The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine
 2014-10
NCT02306083 UNKNOWN
Intraocular Pressure Changes After Glucosamine Sulfate Consumption.
Shahid Beheshti University of Medical Sciences
 2014-07 PHASE3
NCT01906801 COMPLETED
Osteoarthritis; Glucosamine; Diacerein
Ramathibodi Hospital
 2013-07 PHASE4
NCT01893905 COMPLETED
Knee Osteoarthritis
Tedec-Meiji Farma, S.A.
 2013-06 PHASE3
NCT01682694 COMPLETED
Inflammation
Fred Hutchinson Cancer Center
 2012-09
NCT01425853 COMPLETED
Knee Osteoarthritis
Bioiberica
 2011-09 PHASE4
NCT02214095 TERMINATED
Chronic Periodontitis
Ain Shams University
 2012-01 EARLY_PHASE1
NCT04121533 COMPLETED
Osteoarthritis, Knee; Vitamin D Supplementation
Intermountain Health Care, Inc.
 2011-07-28
NCT01293305 UNKNOWN
Osteoarthritis
Azidus Brasil
 2011-11 PHASE3
NCT00691678 COMPLETED
Breast Cancer; Joint Pain
Dawn L. Hershman
 2008-10 PHASE2
NCT00513422 UNKNOWN
Osteoarthritis, Knee
University of Sydney
 2007-10 PHASE4
NCT03209895 COMPLETED
Joint Pain
U.S. Nutraceuticals, LLC
 2010-10-08
NCT00955552 COMPLETED
Osteoarthritis of the Knee
Eurofarma Laboratorios S.A.
 2010-08 PHASE3
NCT02010918 COMPLETED
Knee Osteoarthritis
Ache Laboratorios Farmaceuticos S.A.
 2009-02 PHASE3
NCT00805519 COMPLETED
Osteoarthritis of the Knee
Ardabil University of Medical Sciences
 2009-02 PHASE4
NCT00860873 COMPLETED
Osteoarthrosis
Azidus Brasil
 2009-10 PHASE3
NCT02410785 COMPLETED
Overweight and Obesity
Certmedica International GmbH
 2009-08
NCT00720239 COMPLETED
Venous Stasis Ulcers; Venous Insufficiency
Medical University of South Carolina
 2008-02 EARLY_PHASE1
NCT00404079 COMPLETED
Low Back Pain
Ullevaal University Hospital
 2006-12 PHASE4
NCT00377286 COMPLETED
Osteoarthritis
University of Pittsburgh
 2006-09
NCT00833157 UNKNOWN
Osteoarthritis of the Knee
Bispebjerg Hospital
 2005-02 PHASE1
NCT01271218 COMPLETED
Knee Osteoarthritis
Texas A&M University
 2005-11 PHASE4
NCT00703989 COMPLETED
Type 1 Diabetes
Albert Einstein College of Medicine
 2005-02
NCT00452101 COMPLETED
Osteoarthritis of the Knee
Marigot Ltd.
 2006-01 PHASE1; PHASE2
NCT00086229 COMPLETED
Osteoarthritis
National Center for Complementary and Integrative Health (NCCIH)
 2004-04
NCT00317655 COMPLETED
Back Pain
Ferrosan AS
 2006-04 PHASE4
NCT01172249 UNKNOWN
Osteoarthritis, Knee
Mantecorp Industria Quimica e Farmaceutica Ltd.
 PHASE3
NCT00032890 COMPLETED
Osteoarthritis
US Department of Veterans Affairs
 2000-04 PHASE3
NCT00110474 COMPLETED
Knee Osteoarthritis
Rottapharm
 2000-05 PHASE3
NCT00065377 COMPLETED
Obesity; Insulin Resistance
National Center for Complementary and Integrative Health (NCCIH)
 2003-07 PHASE1
NCT00251069 COMPLETED
Osteoarthritis
Slidgigtinstituttet
 2005-04 PHASE4

(data from https://clinicaltrials.gov, updated on 2026-05-12)

Check the Glucosamine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Glucosamine functions as an essential amino sugar precursor in glycosaminoglycan and proteoglycan biosynthesis while selectively downregulating hypoxia-inducible factor-1α (HIF-1α) protein levels via interference with citric acid cycle metabolite production. This metabolic action modulates extracellular matrix synthesis and attenuates cellular hypoxic responses, supporting its clinical evaluation for osteoarthritis-associated joint degeneration and neoplastic tissues.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.