CAS No. 3416-24-8
Batch:
Purity:97
Chemical Structure
Check the
Glucosamine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol | |
|---|---|---|
| CAS Number | 3416-24-8 | |
| Molecular Formula |
C6H13NO5 |
|
| Molecular Weight (MW) | 179.17 | |
| SMILES | NC(C=O)C(O)C(O)C(O)CO | |
| InChIKey | MSWZFWKMSRAUBD-IVMDWMLBSA-N |
Biological Activity
Glucosamine is an amino sugar and a biochemical precursor in the synthesis of glycosylated proteins and lipids. In cellular models, glucosamine selectively downregulates hypoxia-inducible factor-1α (HIF-1α) at the protein level by interfering with the production of citric acid cycle metabolites. This downregulation inhibits downstream hypoxic signaling and cellular metabolic pathways, suppressing tumor cell proliferation and survival.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
36 mg/mL
(200.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 36 mg/mL |
| Ethanol | Insoluble |
| Water | 36 mg/mL |
| DMSO |
23 mg/mL
(128.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Jump to
Note: Technical data last updated: Sep 1, 2026.