CAS No. 3416-24-8
Batch:
Purity:97
Chemical Structure
Check the
Glucosamine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol | |
|---|---|---|
| CAS Number | 3416-24-8 | |
| Molecular Formula |
C6H13NO5 |
|
| Molecular Weight (MW) | 179.17 | |
| SMILES | NC(C=O)C(O)C(O)C(O)CO | |
| InChIKey | MSWZFWKMSRAUBD-IVMDWMLBSA-N |
Glucosamine is an amino sugar and a biochemical precursor in the synthesis of glycosylated proteins and lipids. In cellular models, glucosamine selectively downregulates hypoxia-inducible factor-1α (HIF-1α) at the protein level by interfering with the production of citric acid cycle metabolites. This downregulation inhibits downstream hypoxic signaling and cellular metabolic pathways, suppressing tumor cell proliferation and survival.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
36 mg/mL
(200.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 36 mg/mL |
| Ethanol | Insoluble |
| Water | 36 mg/mL |
| DMSO |
23 mg/mL
(128.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.