Setanaxib (GKT137831): Selectivity & Specificity

Setanaxib (GKT137831) is a potent inhibitor of NOX1 (100 –150 nM), NOX4 (100 –150 nM), NOX5. Setanaxib (GKT137831) exhibits the greatest inhibitory potency toward NOX1 and NOX4 (IC50 = 100 –150 nM).