Fludarabine SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

• Product Name: Fludarabine
• Catalog Number: S1491
• CAS Number: 21679-14-1
• IUPAC Name: (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol

Relevant identified uses and uses advised against

• Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
• Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

• Company : Selleck Chemicals
• TollFree : +1 877 796-6397
• Tel : +1 832 582-8158
• Fax : +1 832 582-8590

Emergency telephone number

• Emergency phone #: +1 832 582-8158

2. Hazards identification

2.1 Classification of the substance or mixture

GHS Classification in accordance with 29 CFR 1910 (OSHA HCS):

• Germ cell mutagenicity (Category 2), H341
• Reproductive toxicity (Category 2), H361

2.2 GHS Label elements, including precautionary statements

Signal Word: Warning

Hazard Statements:

• H341: Suspected of causing genetic defects.
• H361: Suspected of damaging fertility or the unborn child.

Precautionary Statements:

• P201: Obtain special instructions before use.
• P202: Do not handle until all safety precautions have been read and understood.
• P280: Wear protective gloves/ protective clothing/ eye protection/ face protection.
• P308 + P313: IF exposed or concerned: Get medical advice/ attention.
• P405: Store locked up.
• P501: Dispose of contents/ container to an approved waste disposal plant.

2.3 Hazards not otherwise classified (HNOC) or not covered by GHS

None.

3. Composition/information on ingredients

3.2 Mixtures

Synonyms: 2-FLUOROADENINE 9-B-D-ARABINOFURANOSIDE
Formula: (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol
Molecular weight: 285.23 g/mol

Components:

• Fludarabine (CAS-No. 21679-14-1): Concentration >= 90 - <= 100 %. Classification: Muta. 2; Repr. 2; H341, H361.
• Methanol (CAS-No. 67-56-1): Concentration >= 1 - < 3 %. Classification: Flam. powder 2; Acute Tox. 3; STOT SE 1; H225, H301, H331, H311, H370. Concentration limits: >= 10 %: STOT SE 1, H370; 3 - < 10 %: STOT SE 2, H371.

4. First aid measures

4.1 Description of first-aid measures

• General advice: Show this safety data sheet to the doctor in attendance.
• If inhaled: After inhalation, move to fresh air. Call a physician.
• In case of skin contact: Take off contaminated clothing immediately. Rinse skin with water/shower. Consult a physician.
• In case of eye contact: After eye contact, rinse out with plenty of water. Remove contact lenses. Call an ophthalmologist.
• If swallowed: Immediately make the victim drink water (two glasses at most). Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11.

4.3 Indication of any immediate medical attention and special treatment needed

N/A.

5. Firefighting measures

5.1 Extinguishing media

• Suitable extinguishing media: Water, Foam, Carbon dioxide (CO2), powder.
• Unsuitable extinguishing media: No limitations of extinguishing agents are given for this substance/mixture.

5.2 Special hazards arising from the substance or mixture

Carbon oxides, Nitrogen oxides (NOx), Hydrogen fluoride. Combustible. Development of hazardous combustion gases or vapours is possible in the event of fire.

5.3 Advice for firefighters

Stay in the danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

5.4 Further information

Suppress gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

6. Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Avoid inhalation of powder. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, and consult an expert. For personal protection see section 8.

6.2 Environmental precautions

Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of powder.

6.4 Reference to other sections

For disposal see section 13.

7. Handling and storage

7.1 Precautions for safe handling

For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Storage conditions: Tightly closed. Dry. Keep locked up or in an area accessible only to qualified or authorized persons.
Recommended storage temperature: 2 - 8 °C.
Storage class (TRGS 510): 11: Combustible powder.

7.3 Specific end use(s)

Apart from the uses mentioned in section 1.2, no other specific uses are stipulated.

8. Exposure controls/personal protection

8.1 Control parameters

Methanol (CAS-No. 67-56-1):

• TWA: 200 ppm (ACGIH, NIOSH, OSHA Z-1, California PEL)
• STEL: 250 ppm (ACGIH, California PEL)
• ST: 250 ppm (NIOSH)
• C: 1,000 ppm (California PEL)
• Biological Occupational Exposure Limits: 15 mg/l Methanol in urine (End of shift).

8.2 Exposure controls

• Appropriate engineering controls: Change contaminated clothing. Preventive skin protection is recommended. Wash hands after working with the substance.
• Eye/face protection: Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166 (EU). Safety glasses.
• Skin protection: Handle with impervious nitrile rubber gloves (minimum layer thickness: 0.11 mm; break through time: 480 min).
• Body Protection: Protective clothing.
• Respiratory protection: Required when powder is generated. Recommended Filter type: Filter type P3.
• Control of environmental exposure: Do not let product enter drains.

9. Physical and chemical properties

9.1 Information on basic physical and chemical properties

• a) Appearance: Form: powder; Color: white
• b) Odor: N/A
• c) Odor Threshold: N/A
• d) pH: N/A
• e) Melting point/freezing point: N/A
• f) Initial boiling point and boiling range: N/A
• g) Flash point: N/A
• h) Evaporation rate: N/A
• i) Flammability (powder, gas): N/A
• j) Upper/lower flammability or explosive limits: N/A
• k) Vapor pressure: N/A
• l) Vapor density: N/A
• m) Density: N/A; Relative density: N/A
• n) Water solubility: N/A
• o) Partition coefficient: n-octanol/water: log Pow: -0.790
• p) Autoignition temperature: N/A
• q) Decomposition temperature: N/A
• r) Viscosity: N/A
• s) Explosive properties: N/A
• t) Oxidizing properties: N/A

9.2 Other safety information

N/A.

10. Stability and reactivity

10.1 Reactivity

Flammable organic substances and mixtures in fine distribution may generally have a powder explosion potential when whirled up.

10.2 Chemical stability

The product is chemically stable under standard ambient conditions (room temperature).

10.3 Possibility of hazardous reactions

N/A.

10.4 Conditions to avoid

No information available.

10.5 Incompatible materials

Strong oxidizing agents.

10.6 Hazardous decomposition products

In the event of fire: see section 5.

11. Toxicological information

11.1 Information on toxicological effects

Mixture:

• Acute toxicity: Oral ATE > 5,000 mg/kg; Inhalation ATE (4 h) > 200 mg/l (powder); Dermal ATE > 5,000 mg/kg.
• Skin/Eye: N/A.
• Germ cell mutagenicity: Evidence of genetic defects.
• Carcinogenicity: No ingredient present at levels >= 0.1% is identified as a known or anticipated carcinogen by IARC, NTP, or OSHA.
• Reproductive toxicity: Suspected of damaging the unborn child and fertility.
• Additional Information: RTECS: AU6207000. Based on human evidence, may cause central nervous system effects and breathing difficulties.

Components - Fludarabine:

• Germ cell mutagenicity: Suspected of causing genetic defects.
• Reproductive toxicity: Suspected of damaging the unborn child.

Components - Methanol:

• Acute toxicity: Oral ATE 100.1 mg/kg (Nausea, Vomiting); Inhalation ATE (4 h) 3.1 mg/l (powder) (Respiratory tract irritation); Dermal ATE 300.1 mg/kg.
• Sensitisation: Negative (OECD 406).
• STOT - single exposure: Causes damage to organs (Eyes, Central nervous system).

12. Ecological information

12.1 Toxicity

Mixture: N/A.

Components - Methanol:

• Fish: LC50 - Lepomis macrochirus (Bluegill) - 15,400.0 mg/l - 96 h.
• Daphnia: EC50 - Daphnia magna (Water flea) - 18,260 mg/l - 96 h.
• Algae: ErC50 - Pseudokirchneriella subcapitata - ca. 22,000.0 mg/l - 96 h.
• Bacteria: IC50 - activated sludge - > 1,000 mg/l - 3 h.

12.2 Persistence and degradability

N/A.

12.3 Bioaccumulative potential

N/A.

12.4 Mobility in soil

N/A.

12.5 Results of PBT and vPvB assessment

PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.

12.6 Endocrine disrupting properties

N/A.

16. OTHER INFORMATION

Revision Date: 2026/07/29
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.