Fludarabine: Mechanism of Action

Fludarabine MOA:Targeting DNA Polymerase/Apoptosis Pathway for CAR-T Cell Therapy Conditioning

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Fludarabine is a potent purine nucleoside analog and STAT1 inhibitor. It affects JAK/STAT and DNA damage response signaling by inhibiting STAT1 phosphorylation and DNA synthesis, effectively inducing cancer cell apoptosis, mitigating M1 macrophage polarization, and suppressing viral replication.

Primary Applications and Mechanism of Action