CAS No. 21679-14-1
Batch:
Purity:99.95
Chemical Structure
Check the
Fludarabine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol | |
|---|---|---|
| CAS Number | 21679-14-1 | |
| Molecular Formula |
C10H12FN5O4 |
|
| Molecular Weight (MW) | 285.23 | |
| SMILES | C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)O)F)N | |
| InChIKey | HBUBKKRHXORPQB-FJFJXFQQSA-N |
Biological Activity
Fludarabine is a purine nucleoside analog that acts as a STAT1 activation inhibitor and DNA synthesis inhibitor. By selectively suppressing STAT1 protein activation and expression, fludarabine impairs downstream signaling pathways. Consequently, treatment induces cell cycle arrest at the G1 phase, disrupts mitochondrial membrane potential, and triggers caspase-dependent cleavage leading to apoptosis in cancer cells. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(199.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
57 mg/mL
(199.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
57 mg/mL
(199.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
57 mg/mL
(199.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- Fludarabine Mechanism of Action: DNA Polymerase Inhibition in T Lymphocytes Research
- Fludarabine Clinical Trials
- Fludarabine Working Concentration | Cell Culture | Treatment
- Fludarabine Solubility in DMSO
- Fludarabine Stock Solution
- Fludarabine Storage
- Fludarabine Stability
- Fludarabine Combination Database
- Fludarabine Molecular Weight
- Fludarabine SMILES
- Fludarabine Chemical Structure (2D and 3D)
- Fludarabine IC50 for Cell-based and Cell-free Assays
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Note: Technical data last updated: Sep 1, 2026.