Fludarabine is a potent purine nucleoside analog and STAT1 inhibitor. It affects JAK/STAT and DNA damage response signaling by inhibiting STAT1 phosphorylation and DNA synthesis, effectively inducing cancer cell apoptosis, mitigating M1 macrophage polarization, and suppressing viral replication.
Fludarabine IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Fludarabine Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.