Entinostat (MS-275): Selectivity & Specificity
Entinostat (MS-275) is a potent inhibitor of HDAC1 (163 nM), HDAC2 (396 nM), HDAC3 (605 nM), HDACs (Class I), HDACs (Class IV), AKT, MCL1, E2F, MYC, PSA, Brachyury, CEA, MUC1, FRK, RelA, Histone H3, RARB, NCOR, ER, Aromatase, HER2, HER2/MAPK, DNA methylation, Histone deacetylation, RCB, GATA3, NO. Entinostat (MS-275) exhibits the greatest inhibitory potency toward HDAC1 (IC50 = 163 nM).