CAS No. 209783-80-2
Chemical Information
| IUPAC Name | pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate | |
|---|---|---|
| CAS Number | 209783-80-2 | |
| Molecular Formula |
C21H20N4O3 |
|
| Molecular Weight (MW) | 376.41 | |
| SMILES | C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3 | |
| InChIKey | INVTYAOGFAGBOE-UHFFFAOYSA-N |
Biological Activity
Entinostat (MS-275) is an synthetic benzamide histone deacetylase (HDAC) inhibitor that selectively targets HDAC1 and HDAC3. By inhibiting HDAC activity, Entinostat induces histone hyperacetylation, disrupting chromatin structure and regulating gene expression. This pathway modulation promotes downstream cellular responses including cell cycle arrest, autophagy, and apoptosis. In prostate cancer cell lines, Entinostat exerts dose-dependent growth inhibition in PC-3 and LNCaP cells, while triggering cell death in DU-145 cells. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
| Solvent | Solubility & Note |
|---|---|
| DMSO |
75 mg/mL
(199.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
75 mg/mL
(199.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
75 mg/mL
(199.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- Entinostat (MS-275) Mechanism of Action: HDAC1 Inhibition in Breast Cancer Cell Research
- Entinostat (MS-275) Clinical Trials
- Entinostat (MS-275) Working Concentration | Cell Culture | Treatment
- Entinostat (MS-275) Solubility in DMSO
- Entinostat (MS-275) Stock Solution
- Entinostat (MS-275) Storage
- Entinostat (MS-275) Stability
- Entinostat (MS-275) Combination Database
- Entinostat (MS-275) Molecular Weight
- Entinostat (MS-275) SMILES
- Entinostat (MS-275) Chemical Structure (2D and 3D)
- Entinostat (MS-275) IC50 for Cell-based and Cell-free Assays
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