Dinaciclib (SCH 727965): Selectivity & Specificity

Dinaciclib (SCH 727965) is a potent inhibitor of CDK2 (1 nM), CDK5 (1 nM), CDK1 (3 nM), CDK9 (4 nM), CDK4 (60-100 nM), CDK6 (60-100 nM), CDK7 (60-100 nM), CDK (7.5 nM), MCL1, PARP, CDK12. Dinaciclib (SCH 727965) exhibits the greatest inhibitory potency toward CDK2 and CDK5 (IC50 = 1 nM).