CAS No. 779353-01-4
Batch:
Purity:99.99
-chemical-structure-s2768.gif)
Chemical Structure
Check the
Dinaciclib (SCH 727965)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol | |
|---|---|---|
| CAS Number | 779353-01-4 | |
| Molecular Formula |
C21H28N6O2 |
|
| Molecular Weight (MW) | 396.49 | |
| SMILES | CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCCC4CCO | |
| InChIKey | PIMQWRZWLQKKBJ-SFHVURJKSA-N |
Dinaciclib (SCH 727965) is a potent inhibitor of CDK2 (IC50 1 nM), CDK5 (IC50 1 nM), CDK1 (IC50 3 nM), and CDK9 (IC50 4 nM). It blocks thymidine incorporation into DNA and suppresses retinoblastoma protein phosphorylation. By disrupting cell cycle progression and RNA polymerase II transcription, Dinaciclib induces apoptosis through caspase-8 and caspase-9 activation across a broad spectrum of human tumor cells. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(199.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 35 mg/mL |
| Water | Insoluble |
| DMSO |
79 mg/mL
(199.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 49 mg/mL |
| Water | Insoluble |
| DMSO |
79 mg/mL
(199.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 40 mg/mL |
| Water | Insoluble |
| DMSO |
79 mg/mL
(199.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
| DMSO |
79 mg/mL
(199.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 9 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Dinaciclib (SCH 727965) Mechanism of Action: CDK9 Inhibition in Leukemic Cell Research
- Dinaciclib (SCH 727965) Clinical Trials
- Dinaciclib (SCH 727965): Selectivity & Specificity
- Dinaciclib (SCH 727965) Working Concentration | Cell Culture | Treatment
- Dinaciclib (SCH 727965) Solubility in DMSO
- Dinaciclib (SCH 727965) Stock Solution
- Dinaciclib (SCH 727965) Storage
- Dinaciclib (SCH 727965) Stability
- Dinaciclib (SCH 727965) Combination Database
- Dinaciclib (SCH 727965) Molecular Weight
- Dinaciclib (SCH 727965) SMILES
- Dinaciclib (SCH 727965) Chemical Structure (2D and 3D)
- Dinaciclib (SCH 727965) IC50 for Cell-based and Cell-free Assays
- Dinaciclib (SCH 727965) Sigma (SML3722)? Try a better option.
- Dinaciclib (SCH 727965) MedChemExpress (HY-10492)? Try a better option.
- Dinaciclib (SCH 727965) Cayman (14707)? Try a better option.
- Dinaciclib (SCH 727965) APExBIO (A8412)? Try a better option.
- Dinaciclib (SCH 727965) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.