DAPT is a potent and cell-permeable γ-secretase inhibitor. It affects Notch and amyloid precursor protein (APP) signaling by blocking the proteolytic cleavage of Notch receptors and APP, effectively inhibiting amyloid-beta (Aβ) production and downstream Notch pathway activation.
DAPT IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for DAPT Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.