Clinical Trials

Numerous clinical trials evaluate therapeutic interventions for conditions including ischemic stroke, coronary artery disease, acute coronary syndrome, baseline thrombocytopenia, and NK/T cell lymphoma. Spanning Early Phase 1 through Phase 4, these studies are supported by academic, health system, and industry sponsors, with statuses encompassing recruiting, active not recruiting, completed, and terminated protocols. Research within this network focuses on interventions such as genotype-guided regimens, antithrombotic strategies, and outcomes following drug-eluting stent implantation.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07592507 NOT_YET_RECRUITING
Stable Angina Pectoris; Coronary Artery Disease
Daejeon St. Mary's hospital
 2026-05 PHASE4
NCT07195149 RECRUITING
Chronic Coronary Syndrome; Stable Coronary Artery Disease CAD
Dolnośląskie Centrum Chorób Serca im.prof. Zbigniewa Religi MEDINET Sp. z o.o.
 2025-11-25 PHASE3
NCT07587099 RECRUITING
Coronary Heart Disease (CHD)
Gan Lijun
 2026-05-04
NCT06276374 RECRUITING
Carotid Artery Diseases
Woo-Keun Seo
 2024-07-15
NCT06718179 RECRUITING
Acute Coronary Syndrome
Odense University Hospital
 2024-11-16 PHASE4
NCT07164859 NOT_YET_RECRUITING
Coronary Artery Disease (CAD); Percutaneous Coronary Intervention (PCI); Antiplatelet Therapy; Elderly (People Aged 65 or More)
Vincent ROULE
 2025-10 PHASE3
NCT07198529 RECRUITING
Stable Angina; Coronary Artery Disease
Korea University Guro Hospital
 2025-09-30
NCT06014060 RECRUITING
Elevated Lipoprotein(a) Level; Coronary Artery Disease; Drug-Eluting Stent; Dual Antiplatelet Therapy
China National Center for Cardiovascular Diseases
 2025-06-20
NCT07374718 NOT_YET_RECRUITING
Acute Coronary Syndrome (ACS); High Bleeding Risk(HBR); Coronary Artery Disease (CAD)
Shenyang Northern Hospital
 2026-03-01
NCT05262803 RECRUITING
Myocardial Infarction
Rikke Sorensen
 2022-06-17 PHASE4
NCT07761598 NOT_YET_RECRUITING
Aneurysm Cerebral
Jacobs institute
 2026-08
NCT05650411 RECRUITING
Left Main Coronary Artery Stenosis
IGLESIAS Juan Fernando
 2026-04-26
NCT07195812 NOT_YET_RECRUITING
ST Elevation Myocardial Infarction; No-Reflow Phenomenon
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2025-10 PHASE4
NCT06283888 RECRUITING
ACS - Acute Coronary Syndrome; CYP2C19 Polymorphism
Zunyi Medical College
 2024-04-01 PHASE4
NCT06943586 RECRUITING
Stroke; Transient Ischemic Attack (TIA)
University of Alabama at Birmingham
 2025-04-09
NCT07111559 RECRUITING
Lacunar Stroke; Stroke; Ischemic Stroke
Nippon Medical School
 2025-08-01 PHASE4
NCT06648720 NOT_YET_RECRUITING
Coronary Arterial Disease (CAD); Percutaneous Coronary Intervention (PCI); Intravascular Ultrasound; Dual Antiplatelet Therapy
University Medical Center Ho Chi Minh City (UMC)
 2025-03-01
NCT06535568 RECRUITING
Coronary Disease; Heart Diseases; Cardiovascular Diseases; Myocardial Ischemia; Atherosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Coronary Artery Disease; Acute Coronary Syndrome; Coronary Stenosis; Molecular Mechanisms of Pharmacological Action; Enzyme Inhibitors; MTOR Inhibitors; Protein Kinase Inhibitors; Physiological Effects of Drugs; Immunosuppressive Agents; Antineoplastic Agents; High Bleeding Risk; Single Antiplatelet Therapy; Dual Antiplatelet Therapy; Cyclooxygenase Inhibitors; P2Y12 Inhibitor; Platelet Aggregation Inhibitors; Aspirin; Clopidogrel
Fondazione Ricerca e Innovazione Cardiovascolare ETS
 2026-01-10
NCT05732701 RECRUITING
Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Coronary Artery Disease
Insel Gruppe AG, University Hospital Bern
 2023-06-27
NCT04436978 RECRUITING
Acute Coronary Syndrome; Myocardial Infarction; Atrial Fibrillation; Atrial Flutter; STEMI - ST Elevation Myocardial Infarction; NSTEMI - Non-ST Segment Elevation MI; Bleeding; Stroke; Stent Thrombosis; Embolism; Coronary Artery Disease
St. Antonius Hospital
 2023-01-11 PHASE4
NCT05491200 RECRUITING
ST Elevated Myocardial Infarction; Dual Antiplatelet Therapy
Research Maatschap Cardiologen Rotterdam Zuid
 2022-07-22 PHASE4
NCT05936606 RECRUITING
Coronary Artery Disease
Yonsei University
 2023-08-16
NCT05952206 ACTIVE_NOT_RECRUITING
Coronary Artery Disease
iVascular S.L.U.
 2023-10-13 PHASE3
NCT06013020 RECRUITING
STEMI - ST Elevation Myocardial Infarction
Zunyi Medical College
 2024-04-01 PHASE4
NCT04937699 RECRUITING
Acute Coronary Syndrome; Percutaneous Coronary Intervention
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2023-03-28 PHASE4
NCT06216821 RECRUITING
Acute Coronary Syndrome
Shenyang Northern Hospital
 2024-07-02
NCT06339021 NOT_YET_RECRUITING
Optical Coherence Tomography; Dual Antiplatelet Therapy; Antiplatelet De-escalation; Neointimal Coverage; ST Elevation Myocardial Infarction
Shenyang Northern Hospital
 2024-04-01 EARLY_PHASE1
NCT07000617 RECRUITING
NK/T Cell Lymphoma
Peking University Cancer Hospital & Institute
 2025-03-21 PHASE2
NCT06588595 RECRUITING
Coronary Arterial Disease (CAD)
University of Florida
 2024-11-01 PHASE4
NCT06916520 RECRUITING
Coronary Arterial Disease (CAD); Percutaneous Coronary Intervention (PCI)
J.P.S Henriques
 2025-11-13 PHASE4
NCT05782270 RECRUITING
Anticoagulation; Coronary Endarterectomy
China National Center for Cardiovascular Diseases
 2023-04-11 PHASE4
NCT04624854 COMPLETED
Coronary Artery Disease; Myocardial Ischemia; Acute Coronary Syndrome; Heart Diseases; Syndrome Heart Disease; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Coronary Disease; Vascular Diseases
Harbin Medical University
 2020-10-28 PHASE4
NCT07238764 COMPLETED
High Bleeding Risk Patients; DAPT(Dual Antiplatelet Therapy); Coronary Artery Disease; Diabetes Mellitus
Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
 2022-06-12
NCT04753749 COMPLETED
Myocardial Infarction, Acute; Coronary Artery Disease
MicroPort CRM
 2021-03-25
NCT03797651 UNKNOWN
Coronary Artery Disease, Acute Coronary Syndrome
Yonsei University
 2019-04-24
NCT05709626 RECRUITING
ST-segment Elevation Myocardial Infarction (STEMI)
Kindai University
 2023-02-28 PHASE4
NCT05631769 ACTIVE_NOT_RECRUITING
Coronary Artery Disease; Acute Myocardial Infarction; Stable Angina
Seoul National University Hospital
 2020-07-24 PHASE4
NCT04135677 UNKNOWN
Left Atrial Appendage Thrombosis; Thrombi; Stroke
Shanghai Zhongshan Hospital
 2022-11-11 PHASE4
NCT06292117 Recruiting
Ischemic Stroke|CYP2C19 Polymorphism
University of Virginia|American Heart Association
 2024-04-16 --
NCT03729401 TERMINATED
Coronary Artery Disease; Myocardial Infarction
Ottawa Heart Institute Research Corporation
 2019-08-22 PHASE4
NCT05066789 TERMINATED
Coronary Artery Disease
Samsung Medical Center
 2022-01-17 PHASE4
NCT06074549 Recruiting
Coronary Artery Disease
Elixir Medical Corporation
 2024-03-10 --
NCT04609111 UNKNOWN
Acute Coronary Syndrome
Kyoto University, Graduate School of Medicine
 2021-01-29 PHASE4
NCT05770674 UNKNOWN
Coronary Artery Disease
Kiyuk Chang
 2022-04-01
NCT03971500 ACTIVE_NOT_RECRUITING
Coronary Artery Disease
Nanjing First Hospital, Nanjing Medical University
 2019-08-20
NCT02494895 UNKNOWN
Acute Coronary Syndrome
Yonsei University
 2015-08-01 PHASE4
NCT05077683 COMPLETED
Myocardial Infarction, Acute; Left Ventricular Thrombus
Assistance Publique - Hôpitaux de Paris
 2021-10-10 PHASE3
NCT04137510 COMPLETED
Coronary Artery Disease
Biotronik AG
 2020-02-24 PHASE4
NCT06223607 Recruiting
Baseline Thrombocytopenia
Methodist Health System
 2022-08-22 --
NCT04006288 COMPLETED
Coronary Artery Disease
University of Florida
 2019-09-06 PHASE4
NCT03462498 UNKNOWN
Acute Coronary Syndrome; Acute Myocardial Infarction; Coronary Artery Disease; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors
Kyoto University, Graduate School of Medicine
 2018-04-02 PHASE4
NCT03606642 TERMINATED
Coronary Artery Disease; Atherosclerosis; Stent Placement
HonorHealth Research Institute
 2018-11-19 PHASE2
NCT03716011 UNKNOWN
Coronary Artery Disease
JW Medical Systems Ltd
 2018-12-20
NCT03775746 UNKNOWN
Acute Coronary Syndrome
East and North Hertfordshire NHS Trust
 2019-01-08 PHASE4
NCT03284827 COMPLETED
Aortic Valve Stenosis
Duk-Woo Park, MD
 2018-03-15 PHASE4
NCT04135989 UNKNOWN
Coronary Artery Disease; Acute Coronary Syndrome; Chronic Coronary Syndrome; Myocardial Infarction
Federico II University
 2020-01-01 PHASE4
NCT02601157 COMPLETED
Stable Angina; Unstable Angina; Non-ST Segment Elevation Myocardial Infarction
Seoul National University Hospital
 2016-01-18 PHASE4
NCT03287167 UNKNOWN
Coronary Disease; Drug Eluting Stent; Percutaneous Coronary Intervention; Dual Antiplatelet Therapy
Shanghai MicroPort Medical (Group) Co., Ltd.
 2019-06-01 PHASE4
NCT03023020 COMPLETED
High Bleeding Risk; Coronary Artery Disease; PCI
ECRI bv
 2017-04-04
NCT03008083 UNKNOWN
Drug-Eluting Stents; Percutaneous Coronary Intervention
Shanghai MicroPort Medical (Group) Co., Ltd.
 2019-01-10 PHASE4
NCT03218787 COMPLETED
Coronary Artery Lesions
Abbott Medical Devices
 2017-07-19
NCT03815175 COMPLETED
Bleeding Disorder; Ischemic Stroke; Hemorrhagic Stroke; Hematological Diseases; Thrombocytopenia; Coagulation Disorder; Anemia; Renal Insufficiency; Coronary Artery Disease
Abbott Medical Devices
 2019-02-25
NCT02798913 UNKNOWN
Peripheral Artery Disease
Federico II University
 2016-01 PHASE3
NCT03647475 COMPLETED
Coronary Artery Disease
Medtronic Vascular
 2018-10-01
NCT03848572 COMPLETED
Cardiovascular Diseases; Interventional Cardiology
University of Roma La Sapienza
 2017-06-01
NCT03355742 COMPLETED
Bleeding Disorder; Stroke, Ischemic; Stroke Hemorrhagic; Hematological Disease; Thrombocytopenia; Coagulation Disorder; Anemia; Renal Insufficiency; Coronary Artery Disease
Abbott Medical Devices
 2018-02-09
NCT02513810 UNKNOWN
Coronary Artery Disease
Yonsei University
 2015-12-02
NCT02605447 COMPLETED
Coronary Artery Disease
Boston Scientific Corporation
 2016-02-16 PHASE4
NCT05632445 COMPLETED
Left Atrial Appendage Occlusion
DR. XAVIER FREIXA
 2019-05-01 PHASE4
NCT02619760 COMPLETED
Coronary Artery Disease
Kyoto University, Graduate School of Medicine
 2015-12 PHASE4
NCT02609698 UNKNOWN
Stable Angina, Unstable Angina, Silent Coronary Ischemia, Coronary Artery Disease
Ajou University School of Medicine
 2015-08 PHASE4
NCT03273322 COMPLETED
Atrial Fibrillation; Atrial Appendage; Hemorrhage
Assistance Publique - Hôpitaux de Paris
 2017-09-13 PHASE2; PHASE3
NCT03344653 COMPLETED
Coronary Artery Disease
Medtronic Vascular
 2017-11-02
NCT02118870 COMPLETED
Acute Coronary Syndrome
Diagram B.V.
 2014-06-10 PHASE4
NCT01459627 COMPLETED
Myocardial Infarction; Cardiovascular Disease
Maasstad Hospital
 2011-12 PHASE4
NCT02099617 COMPLETED
Stable Angina; Silent Myocardial Ischemia; Acute Coronary Syndrome
Ceric Sàrl
 2014-05
NCT01752894 COMPLETED
Ischemic Heart Disease
Yonsei University
 2013-01-02
NCT02974777 WITHDRAWN
Coronary Arterioscleroses; Platelet Dysfunction Due to Drugs
Kaiser Franz Josef Hospital
 PHASE4
NCT02224235 TERMINATED
Stable Angina
CeloNova BioSciences, Inc.
 2014-06
NCT01106534 COMPLETED
Chronic Total Occlusion of Coronary Artery; Vascular Disease; Myocardial Ischemia; Coronary Artery Stenosis; Coronary Disease; Coronary Artery Disease; Coronary Restenosis
Abbott Medical Devices
 2009-08 PHASE4
NCT02198300 COMPLETED
Coronary Artery Disease
Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland
 2012-11 PHASE4
NCT01069003 COMPLETED
Coronary Artery Disease
Medtronic Vascular
 2010-04 PHASE4
NCT01325935 COMPLETED
Coronary Artery Disease
Associations for Establishment of Evidence in Interventions
 2011-04 PHASE4
NCT00963781 COMPLETED
Coronary Artery Disease; Coronary Thrombosis
Scripps Health
 2009-08 PHASE4
NCT01354808 COMPLETED
Platelet Aggregation Inhibitors; Anti-inflammatory Agent; Myocardial Reperfusion Injury
Gyeongsang National University Hospital
 2010-07 PHASE4
NCT00954707 UNKNOWN
Coronary Artery Disease
Cordis US Corp.
 2009-08 PHASE4

(data from https://clinicaltrials.gov, updated on 2026-05-18)

Check the DAPT product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

DAPT selectively inhibits gamma-secretase, preventing the endoproteolytic cleavage of Notch receptors and amyloid precursor protein to disrupt downstream cell signaling and suppress amyloid-beta production. By driving neuronal differentiation, regulating autophagy, and inducing cell apoptosis, this target blockade underpins experimental strategies against Notch- and cleavage-dependent pathologies, offering therapeutic relevance to clinical study contexts such as ischemic stroke and lymphoma.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.