Target Selectivity of Dapagliflozin (BMS-512148)
| Key Target | IC50 | Description | Reference |
|---|---|---|---|
| SGLT2 | 0.49 nM | Data extracted from Binding Database for half-maximal inhibitory concentration (IC50) or enzyme inhibition constant (Ki) | PMC9421436 |
| SGLT3 | 1.35 nM | Data extracted from Binding Database for half-maximal inhibitory concentration (IC50) or enzyme inhibition constant (Ki) | PMC9421436 |
| SGLT-2 | 1.6 nM | In vitro study | PMC10695710 |
| SGLT1 | 3.2 nM | Data extracted from Binding Database for half-maximal inhibitory concentration (IC50) or enzyme inhibition constant (Ki) | PMC9421436 |
| SGLT6 | 380 nM | Data extracted from Binding Database for half-maximal inhibitory concentration (IC50) or enzyme inhibition constant (Ki) | PMC9421436 |
Check the
Dapagliflozin (BMS-512148)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Cell-free Assays (IC50/Ki) for Dapagliflozin (BMS-512148)
| Key Target | IC50 (Cell-free) | Description | Reference |
|---|---|---|---|
| SGLT2 | 0.49 nM | Data extracted from Binding Database for half-maximal inhibitory concentration (IC50) or enzyme inhibition constant (Ki) | Download PDF |
| SGLT1 | 3.2 nM | Data extracted from Binding Database for half-maximal inhibitory concentration (IC50) or enzyme inhibition constant (Ki) | Download PDF |
| SGLT3 | 1.35 nM | Data extracted from Binding Database for half-maximal inhibitory concentration (IC50) or enzyme inhibition constant (Ki) | Download PDF |
| SGLT6 | 380 nM | Data extracted from Binding Database for half-maximal inhibitory concentration (IC50) or enzyme inhibition constant (Ki) | Download PDF |
Cell-based Assay (IC50) for Dapagliflozin (BMS-512148)
| Cell Type | IC50 (Cell-based) | Description | Reference |
|---|---|---|---|
| HEK293T cells expressing recombinant human Nav1.5 α-subunit | 0.58 µM | Whole-cell patch-clamp recordings of peak- and late-INa | Download PDF |
| 3T3 cells | 68.2 µM | Crystal violet proliferation assay | Download PDF |
| Hepa 1-6 cells | 45.8 µM | Crystal violet proliferation assay | Download PDF |
Jump to
- Dapagliflozin (BMS-512148) Mechanism of Action: SGLT2 Inhibition in Renal Proximal Tubule Epithelial Cells Research
- Dapagliflozin (BMS-512148) Clinical Trials
- Dapagliflozin (BMS-512148) Working Concentration | Cell Culture | Treatment
- Dapagliflozin (BMS-512148) Solubility in DMSO
- Dapagliflozin (BMS-512148) Storage
- Dapagliflozin (BMS-512148) Stability
- Dapagliflozin (BMS-512148) Combination Database
- Dapagliflozin (BMS-512148) Molecular Weight
- Dapagliflozin (BMS-512148) SMILES
- Dapagliflozin (BMS-512148) CAS Number
- Dapagliflozin (BMS-512148) Chemical Structure (2D and 3D)
- Dapagliflozin (BMS-512148) IC50 for Cell-based and Cell-free Assays
- Dapagliflozin (BMS-512148) Sigma (SML2804)? Try a better option.
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- Dapagliflozin (BMS-512148) SDS｜MSDS