CAS No. 461432-26-8
| IUPAC Name | (2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol | |
|---|---|---|
| CAS Number | 461432-26-8 | |
| Molecular Formula |
C21H25ClO6 |
|
| Molecular Weight (MW) | 408.87 | |
| SMILES | CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl | |
| InChIKey | JVHXJTBJCFBINQ-ADAARDCZSA-N |
Dapagliflozin is a potent and selective sodium-glucose cotransporter inhibitor targeting human SGLT2 over SGLT1. By selectively inhibiting SGLT2 in the renal proximal tubules, it reduces renal glucose reabsorption, increases urinary glucose excretion, and lowers plasma glucose levels independently of insulin secretion. These actions modulate systemic glucose homeostasis in preclinical models without impairing SGLT1-mediated intestinal nutrient absorption. [1]
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(244.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
82 mg/mL
(200.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 82 mg/mL |
| Water | Insoluble |
| DMSO |
82 mg/mL
(200.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 17 mg/mL |
| Water | Insoluble |
| DMSO |
82 mg/mL
(200.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 82 mg/mL |
| Water | Insoluble |
| DMSO |
82 mg/mL
(200.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 82 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- Dapagliflozin (BMS-512148) Mechanism of Action: SGLT2 Inhibition in Renal Proximal Tubule Epithelial Cells Research
- Dapagliflozin (BMS-512148) Clinical Trials
- Dapagliflozin (BMS-512148): Selectivity & Specificity
- Dapagliflozin (BMS-512148) Working Concentration | Cell Culture | Treatment
- Dapagliflozin (BMS-512148) Solubility in DMSO
- Dapagliflozin (BMS-512148) Storage
- Dapagliflozin (BMS-512148) Stability
- Dapagliflozin (BMS-512148) Combination Database
- Dapagliflozin (BMS-512148) Molecular Weight
- Dapagliflozin (BMS-512148) SMILES
- Dapagliflozin (BMS-512148) Chemical Structure (2D and 3D)
- Dapagliflozin (BMS-512148) IC50 for Cell-based and Cell-free Assays
- Dapagliflozin (BMS-512148) Sigma (SML2804)? Try a better option.
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- Dapagliflozin (BMS-512148) SDS｜MSDS