Cell-free Assays (IC50/Ki) for Dapagliflozin (BMS-512148)
| Key Target | IC50 (Cell-free) | Description | Reference |
|---|---|---|---|
| SGLT2 | 0.49 nM | Data extracted from Binding Database for half-maximal inhibitory concentration (IC50) or enzyme inhibition constant (Ki) | Download PDF |
| SGLT1 | 3.2 nM | Data extracted from Binding Database for half-maximal inhibitory concentration (IC50) or enzyme inhibition constant (Ki) | Download PDF |
| SGLT3 | 1.35 nM | Data extracted from Binding Database for half-maximal inhibitory concentration (IC50) or enzyme inhibition constant (Ki) | Download PDF |
| SGLT6 | 380 nM | Data extracted from Binding Database for half-maximal inhibitory concentration (IC50) or enzyme inhibition constant (Ki) | Download PDF |
Cell-based Assay (IC50) for Dapagliflozin (BMS-512148)
| Cell Type | IC50 (Cell-based) | Description | Reference |
|---|---|---|---|
| HEK293T cells expressing recombinant human Nav1.5 α-subunit | 0.58 µM | Whole-cell patch-clamp recordings of peak- and late-INa | Download PDF |
| 3T3 cells | 68.2 µM | Crystal violet proliferation assay | Download PDF |
| Hepa 1-6 cells | 45.8 µM | Crystal violet proliferation assay | Download PDF |
Check the
Dapagliflozin (BMS-512148)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
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