Dapagliflozin (BMS-512148) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

• Product Name: Dapagliflozin (BMS-512148)
• Catalog Number: S1548
• CAS Number: 461432-26-8
• IUPAC Name: (2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol

Relevant identified uses and uses advised against

• Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
• Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

• Company : Selleck Chemicals
• TollFree : +1 877 796-6397
• Tel : +1 832 582-8158
• Fax : +1 832 582-8590

Emergency telephone number

• Emergency phone #: +1 832 582-8158

2. HAZARDS IDENTIFICATION

GHS classification in accordance with the OSHA Hazard Communication Standard (29 CFR 1910.1200)

• Acute toxicity (Oral): Category 4
• Eye irritation: Category 2A
• Reproductive toxicity: Category 1B
• Effects on or via lactation
• Specific target organ toxicity - repeated exposure: Category 1 (Kidney)
• Long-term (chronic) aquatic hazard: Category 2

Pictogram: , ,

Signal word: Danger

Hazard statements:

• H302: Harmful if swallowed.
• H319: Causes serious eye irritation.
• H360: May damage fertility or the unborn child.
• H362: May cause harm to breast-fed children.
• H372: Causes damage to organs (Kidney) through prolonged or repeated exposure.
• H411: Toxic to aquatic life with long lasting effects.

Precautionary statements:

Prevention:

• P201: Obtain special instructions before use.
• P202: Do not handle until all safety precautions have been read and understood.
• P260: Do not breathe powder.
• P263: Avoid contact during pregnancy and while nursing.
• P264: Wash skin thoroughly after handling.
• P270: Do not eat, drink or smoke when using this product.
• P273: Avoid release to the environment.
• P280: Wear protective gloves/ protective clothing/ eye protection/ face protection.

Response:

• P301 + P312 + P330: IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth.
• P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P308 + P313: IF exposed or concerned: Get medical advice/ attention.
• P337 + P313: If eye irritation persists: Get medical advice/ attention.
• P391: Collect spillage.

Storage:

• P405: Store locked up.

Disposal:

• P501: Dispose of contents/ container to an approved waste disposal plant.

Other hazards:
None known.

3. COMPOSITION/INFORMATION ON INGREDIENTS

Substance / Mixture: Substance
CAS-No.: 461432-26-8

Components:

• Chemical name: (2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
• CAS No.: 461432-26-8
• Concentration (% w/w): >= 80 - <= 100 (withheld as a trade secret)

4. FIRST AID MEASURES

• General advice: Show this safety data sheet to the doctor in attendance.
• If inhaled: After inhalation: fresh air. Call in physician.
• In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
• In case of eye contact: After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
• If swallowed: After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
• Most important symptoms and effects, both acute and delayed: The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11.
• Protection of first-aiders: For personal protection see section 8.
• Notes to physician: N/A.

5. FIREFIGHTING MEASURES

• Suitable extinguishing media: Water, Foam, Carbon dioxide (CO2), Dry powder.
• Unsuitable extinguishing media: For this substance/mixture no limitations of extinguishing agents are given.
• Specific hazards during fire fighting: Combustible. Development of hazardous combustion gases or vapours possible in the event of fire.
• Hazardous combustion products: Carbon oxides, Hydrogen chloride gas.
• Specific extinguishing methods: N/A.
• Further information: Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
• Special protective equipment for fire-fighters: Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

6. ACCIDENTAL RELEASE MEASURES

• Personal precautions, protective equipment and emergency procedures: Advice for non-emergency personnel: Avoid generation and inhalation of powder in all circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.
• Environmental precautions: Do not let product enter drains.
• Methods and materials for containment and cleaning up: Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of powder.

7. HANDLING AND STORAGE

• Advice on safe handling: Work under hood. Do not inhale substance/mixture. For precautions see section 2.
• Further information on storage conditions: Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorised persons.
• Storage class: 6.1C, Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects.
• Recommended storage temperature: -4 °F / -20 °C.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

• Ingredients with workplace control parameters: Contains no substances with occupational exposure limit values.
• Engineering measures: N/A.
• Personal protective equipment:
  • Respiratory protection: Required when powder is generated. Recommended Filter type: Filter type P3 (based on DIN EN 143, DIN 14387).
  • Hand protection: Nitrile rubber gloves (Full contact: 0.11 mm thickness, >480 min breakthrough; Splash contact: 0.11 mm thickness, >480 min breakthrough). Handle with impervious gloves.
  • Eye protection: Safety glasses tested and approved under government standards such as NIOSH (US) or EN 166 (EU).
  • Skin and body protection: Protective clothing.
  • Hygiene measures: Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

9. PHYSICAL AND CHEMICAL PROPERTIES

• Appearance: powder
• Colour: N/A
• Odour: N/A
• Odour Threshold: N/A
• pH: N/A
• Melting point: N/A
• Boiling point/boiling range: N/A
• Flash point: N/A
• Evaporation rate: N/A
• Flammability (solid, gas): N/A
• Flammability (liquids): N/A
• Burning rate: N/A
• Upper/Lower explosion limit: N/A
• Vapour pressure: N/A
• Relative vapour density: N/A
• Relative density: N/A
• Density: N/A
• Water solubility: N/A
• Partition coefficient: n-octanol/water: log Pow: 2.34 (77 °F / 25 °C); Method: OECD Test Guideline 107. Bioaccumulation is not expected.
• Autoignition temperature: N/A
• Decomposition temperature: N/A
• Viscosity: N/A
• Explosive properties: Not classified as explosive.
• Oxidizing properties: None.
• Molecular weight: 408.87 g/mol
• Particle size: N/A

10. STABILITY AND REACTIVITY

• Reactivity: Flammable organic substances in fine distribution may generally assume a powder explosion potential when whirled up.
• Chemical stability: The product is chemically stable under standard ambient conditions (room temperature).
• Possibility of hazardous reactions: N/A.
• Conditions to avoid: No information available.
• Incompatible materials: Strong oxidizing agents.
• Hazardous decomposition products: In the event of fire: see section 5.

11. TOXICOLOGICAL INFORMATION

• Acute toxicity: Acute toxicity estimate Oral - 500.1 mg/kg (Expert judgement). Inhalation/Dermal: N/A.
• Skin corrosion/irritation: Rabbit - No skin irritation.
• Serious eye damage/eye irritation: Bovine cornea - Moderate eye irritation (Lit.).
• Respiratory or skin sensitization: Local lymph node assay (LLNA) Mouse - Negative.
• Germ cell mutagenicity: Ames test (E. coli/S. typhimurium), Chromosome aberration (CHO cells), Unscheduled DNA synthesis (Rat), and In vivo micronucleus test (Rat) were all negative.
• Carcinogenicity: No component identified as a probable, possible or confirmed human carcinogen by IARC, NTP, or OSHA.
• Reproductive toxicity: May damage the unborn child. Studies indicate a hazard to babies during the lactation period.
• STOT - single exposure: N/A.
• STOT - repeated exposure: Causes damage to organs (Kidney) through prolonged or repeated exposure.
• Aspiration hazard: N/A.
• Additional Information: Repeated dose toxicity studies in rats (28 d, 84 d, 182 d) showed NOAEL values ranging from 25 to 50 mg/kg. Toxicological properties have not been thoroughly investigated.

12. ECOLOGICAL INFORMATION

• Ecotoxicity:
  • Toxicity to algae: NOEC (Pseudokirchneriella subcapitata) - 37 mg/l (72 h).
  • Toxicity to fish: NOEC (Pimephales promelas) - 1 mg/l (Chronic).
  • Toxicity to daphnia: NOEC (Daphnia) - 10 mg/l (21 d).
• Persistence and degradability: N/A.
• Bioaccumulative potential: log Pow: 2.34. Bioaccumulation is not expected.
• Mobility in soil: N/A.
• Other adverse effects: This product does not contain Class I or Class II ODS as defined by the U.S. Clean Air Act.

13. DISPOSAL CONSIDERATIONS

• Disposal methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers. No mixing with other waste

16. OTHER INFORMATION

Revision Date: 2026/07/27
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.