Cabozantinib (XL184) Selectivity & Specificity

Target Selectivity of Cabozantinib (XL184)

Key Target	IC₅₀	Description	Reference
VEGFR2	0.03 nM	--	PMC12718917
RET	0.03 nM	--	PMC12718917
c-KIT	0.03 nM	--	PMC12718917
FLT3	0.03 nM	--	PMC12718917
TIE2	0.03 nM	--	PMC12718917
CSF-1R	0.03 nM	--	PMC12718917
PDGFRα	0.03 nM	--	PMC12718917
Src	0.03 nM	--	PMC12718917
ABL	0.03 nM	--	PMC12718917
VEGFR2	0.035 nM	tyrosine kinase activity assay	PMC9324961
KDR	0.035 nM	In vitro assay	PMC5873445
VEGFR2	0.035 nM	half maximal inhibitory concentration [IC50]	PMC7395054
AXL	0.7 nM	--	PMC12718917
MET	1.3 nM	half maximal inhibitory concentration [IC50]	PMC7395054
c-MET	1.3 nM	--	PMC12718917
c-Met	1.8 nM	tyrosine kinase activity assay	PMC9324961
RET	4 nM	tyrosine kinase activity assay	PMC9324961
c-KIT	4.6 nM	In vitro assay	PMC5873445
KIT	4.6 nM	half maximal inhibitory concentration [IC50]	PMC7395054
RET	5.2 nM	half maximal inhibitory concentration [IC50]	PMC7395054
AXL	7 nM	In vitro assay	PMC5873445
AXL	7 nM	half maximal inhibitory concentration [IC50]	PMC7395054
FLT-3	11.3 nM	In vitro assay	PMC5873445
FLT3	11.3 nM	half maximal inhibitory concentration [IC50]	PMC7395054
TIE-2	14.3 nM	In vitro assay	PMC5873445
TIE-2	14.3 nM	half maximal inhibitory concentration [IC50]	PMC7395054
c-Met	0.03 µM	BPS KDR Assay Kit	PMC10026756
VEGFR-2	0.059 µM	BPS KDR Assay Kit	PMC10026756
RON	124 nM	half maximal inhibitory concentration [IC50]	PMC7395054
EGFR	600 nM	--	PMC12718917
RAF	600 nM	--	PMC12718917
TKRB	600 nM	--	PMC12718917

Check the Cabozantinib (XL184) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.