CAS No. 849217-68-1

Batch: Purity:99.96
Check CoA
Cabozantinib (XL184) Chemical Structure
Chemical Structure
Check the Cabozantinib (XL184) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
CAS Number 849217-68-1
Molecular Formula

C28H24FN3O5
Molecular Weight (MW) 501.51
SMILES COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F
InChIKey ONIQOQHATWINJY-UHFFFAOYSA-N

Ordering Information

Biological Activity

Cabozantinib (XL184) is a potent, multitargeted receptor tyrosine kinase inhibitor targeting VEGFR2 (IC50 = and MET (IC50 =, as well as RET, AXL, KIT, and FLT3. It suppresses MET and VEGFR2 phosphorylation, inhibiting downstream cellular signaling pathways involved in tumor cell proliferation, survival, and migration. In vivo, cabozantinib disrupts tumor vasculature, induces apoptosis, and demonstrates dose-dependent inhibition of tumor growth and tumor regression. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (199.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Aliquotting Service

Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.

Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.

Jump to

Note: Technical data last updated: Sep 1, 2026.