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Cabozantinib (XL184) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

  • Product Name: Cabozantinib (XL184)
  • Catalog Number: S1119
  • CAS Number: 849217-68-1
  • IUPAC Name: N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Relevant identified uses and uses advised against

  • Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
  • Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

  • Company : Selleck Chemicals
  • TollFree : +1 877 796-6397
  • Tel : +1 832 582-8158
  • Fax : +1 832 582-8590

Emergency telephone number

  • Emergency phone #: +1 832 582-8158

2. Hazards identification

2.1 Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS):

  • Acute toxicity, Oral (Category 4), H302
  • Reproductive toxicity (Category 1B), H360
  • Specific target organ toxicity - repeated exposure (Category 2), Bone marrow, Kidney, Endocrine system, Gastrointestinal tract, Liver, H373

2.2 GHS Label elements, including precautionary statements

  • Pictogram: GHS07 (Exclamation mark), GHS08 (Health hazard)
  • Signal Word: Danger
  • Hazard Statements:
    • H302: Harmful if swallowed.
    • H360: May damage fertility or the unborn child.
    • H373: May cause damage to organs (Bone marrow, Kidney, Endocrine system, Gastrointestinal tract, Liver) through prolonged or repeated exposure.
  • Precautionary Statements:
    • P201: Obtain special instructions before use.
    • P202: Do not handle until all safety precautions have been read and understood.
    • P260: Do not breathe powder.
    • P264: Wash skin thoroughly after handling.
    • P270: Do not eat, drink or smoke when using this product.
    • P280: Wear protective gloves/ protective clothing/ eye protection/ face protection.
    • P301 + P312 + P330: IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth.
    • P308 + P313: IF exposed or concerned: Get medical advice/ attention.
    • P405: Store locked up.
    • P501: Dispose of contents/ container to an approved waste disposal plant.

2.3 Hazards not otherwise classified (HNOC) or not covered by GHS
None.

3. Composition/information on ingredients

3.1 Substances

  • Synonyms: N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
  • Formula: C28H24FN3O5
  • Molecular weight: 501.51 g/mol
  • CAS-No.: 849217-68-1
  • EC-No.: 692-846-8

Component Classification:
N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

  • Classification: Acute Tox. 4; Repr. 1B; STOT RE 2; H302, H360, H373
  • Concentation: <= 100 %

4. First aid measures

4.1 Description of first-aid measures

  • General advice: Show this material safety data sheet to the doctor in attendance.
  • If inhaled: After inhalation: fresh air. Call in physician.
  • In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
  • In case of eye contact: After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
  • If swallowed: After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11.

4.3 Indication of any immediate medical attention and special treatment needed
N/A.

5. Firefighting measures

5.1 Extinguishing media

  • Suitable extinguishing media: Water, Foam, Carbon dioxide (CO2), Dry powder.
  • Unsuitable extinguishing media: For this substance/mixture no limitations of extinguishing agents are given.

5.2 Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen fluoride. Combustible. Development of hazardous combustion gases or vapours possible in the event of fire.

5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

5.4 Further information
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

6. Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of powder. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.

6.2 Environmental precautions
Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of powder.

6.4 Reference to other sections
For disposal see section 13.

7. Handling and storage

7.1 Precautions for safe handling

  • Advice on safe handling: Work under hood. Do not inhale substance/mixture.
  • Hygiene measures: Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

  • Storage conditions: Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.
  • Storage stability Recommended storage temperature: -25 - -10 °C
  • Storage class (TRGS 510): 6.1C: Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects.

7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.

8. Exposure controls/personal protection

8.1 Control parameters
Contains no substances with occupational exposure limit values.

8.2 Exposure controls

  • Appropriate engineering controls: Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
  • Eye/face protection: Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses.
  • Skin protection: Handle with impervious gloves. This recommendation applies only to the product stated in the safety data sheet. Full and splash contact material: Nitrile rubber; Minimum layer thickness: 0.11 mm; Break through time: 480 min.
  • Body Protection: Protective clothing.
  • Respiratory protection: Required when powder is generated. Recommended Filter type: Filter type P3. The entrepreneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.
  • Control of environmental exposure: Do not let product enter drains.

9. Physical and chemical properties

9.1 Information on basic physical and chemical properties

  • a) Appearance Form: powder; Color: white
  • b) Odor: N/A
  • c) Odor Threshold: N/A
  • d) pH: N/A
  • e) Melting point/freezing point: N/A
  • f) Initial boiling point and boiling range: N/A
  • g) Flash point: Not applicable
  • h) Evaporation rate: N/A
  • i) Flammability (solid, gas): N/A
  • j) Upper/lower flammability or explosive limits: N/A
  • k) Vapor pressure: N/A
  • l) Vapor density: N/A
  • m) Density: N/A; Relative density: N/A
  • n) Water solubility: N/A
  • o) Partition coefficient: n-octanol/water: N/A
  • p) Autoignition temperature: N/A
  • q) Decomposition temperature: N/A
  • r) Viscosity: N/A
  • s) Explosive properties: Not classified as explosive.
  • t) Oxidizing properties: none

9.2 Other safety information
N/A.

10. Stability and reactivity

10.1 Reactivity
The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a powder explosion potential may generally be assumed.

10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature).

10.3 Possibility of hazardous reactions
Violent reactions possible with: Strong oxidizing agents.

10.4 Conditions to avoid
No information available.

10.5 Incompatible materials
Strong oxidizing agents.

10.6 Hazardous decomposition products
In the event of fire: see section 5.

11. Toxicological information

11.1 Information on toxicological effects

  • Acute toxicity: Oral - 500.1 mg/kg (Expert judgment). Inhalation/Dermal: N/A.
  • Skin corrosion/irritation: N/A.
  • Serious eye damage/eye irritation: N/A.
  • Respiratory or skin sensitization: N/A.
  • Germ cell mutagenicity: N/A.
  • Carcinogenicity: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC, NTP, or OSHA.
  • Reproductive toxicity: May damage the unborn child. May damage fertility.
  • Specific target organ toxicity - single exposure: N/A.
  • Specific target organ toxicity - repeated exposure: May cause damage to organs through prolonged or repeated exposure. (Bone marrow, Kidney, Endocrine system, Gastrointestinal tract, Liver).
  • Aspiration hazard: N/A.

11.2 Additional Information
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

12. Ecological information

12.1 Toxicity
N/A.

12.2 Persistence and degradability
N/A.

12.3 Bioaccumulative potential
N/A.

12.4 Mobility in soil
N/A.

12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.

12.6 Endocrine disrupting properties
N/A.

12.7 Other adverse effects
N/A.

13. Disposal considerations

13.1 Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.

14. Transport information

DOT (US)
Not dangerous goods

IMDG
Not dangerous goods

IATA
Not dangerous goods

Further information
Not classified as dangerous in the meaning of transport regulations.

15. Regulatory information

CERCLA Reportable Quantity
This material does not contain any components with a CERCLA RQ.

SARA 304 Extremely Hazardous Substances Reportable Quantity
This material does not contain any components with a section 304 EHS RQ.

SARA 302 Extremely Hazardous Substances Threshold Planning Quantity
This material does not contain any components with a section 302 EHS TPQ.

SARA 313
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.

Clean Air Act
This product neither contains, nor was manufactured with a Class I or Class II ODS as defined by the U.S. Clean Air Act Section 602 (40 CFR 82, Subpt. A, App.A + B).
This product does not contain any hazardous air pollutants (HAP), as defined by the U.S. Clean Air Act Section 112 (40 CFR 61).
This product does not contain any chemicals listed under the U.S. Clean Air Act Section 112(r) for Accidental Release Prevention (40 CFR 68.130, Subpart F).
This product does not contain any chemicals listed under the U.S. Clean Air Act Section 111 SOCMI Intermediate or Final VOC's (40 CFR 60.489).

Clean Water Act
This product does not contain any Hazardous Substances listed under the U.S. CleanWater Act, Section 311, Table 116.4A.
This product does not contain any Hazardous Chemicals listed under the U.S. CleanWater Act, Section 311, Table 117.3.
This product does not contain any toxic pollutants listed under the U.S. Clean Water Act Section 307
This product does not contain any priority pollutants related to the U.S. Clean Water Act

US State Regulations
Massachusetts Right To Know
No components are subject to the Massachusetts Right to Know Act.
Maine Chemicals of High Concern
Product does not contain any listed chemicals
Vermont Chemicals of High Concern
Product does not contain any listed chemicals
Washington Chemicals of High Concern
Product does not contain any listed chemicals

The ingredients of this product are reported in the following inventories:
TSCA : Product contains substance(s) not listed on TSCA inventory.

TSCA list
No substances are subject to a Significant New Use Rule.
No substances are subject to TSCA 12(b) export notification requirements.

16. OTHER INFORMATION

Revision Date: 2026/06/24
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.

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