For research use only. Not for use in humans.

Ascrinvacumab (Anti-ACVRL1 / ALK-1)

Synonyms: PF-03446962 Cat.No.A2594 Purity:99%

Ascrinvacumab (Anti-ACVRL1 / ALK-1) is a human IgG2 monoclonal antibody targeting ALK-1. It can be used for the treatment of hepatocellular carcinoma (HCC), in patients with advanced solid tumors. It also demonstrates its use in antiangiogenic therapy. MW : 150 KD.

Quality Control

Batch: Purity: 99% Protein concentration: 9.323mg/ml Endotoxin Level: ＜1EU/mg

Specificity

Name	Citation	ALK	Others
TAE684 (NVP-TAE684)	83	+
AP26113-analog (ALK-IN-1)	4	++++	EGFR(C797S/del19),IGF1R,EGFR(del19)
GSK1838705A	18	+++	Insulin Receptor,IGF-1R
AZD3463	7	+++	IGF-1R
ASP3026	4	++
NVL-655 (Neladalkib)	1	+++	ROS1,TrkB,FAK
Envonalkib	0	++
TL13-112	0	+++
ZX-29	0	++
MS4078	0	+
Ensartinib dihydrochloride	7	+	TPM3-TRKA,GOPC-ROS1,TRKC
Belizatinib (TSR-011)	0	+++	TrkC,TrkB,TrkA
Repotrectinib (TPX-0005)	12	++	Trk receptor,ROS1,Src
APG-2449	0	✔
Iruplinalkib	0	✔	ROS1
Conteltinib(CT-707)	0	✔	Pyk2,FAK
Itacnosertib (TP-0184)	0	✔
Zilurgisertib fumarate	0	✔
ALK inhibitor 1	0	✔	FAK,TSSK2
X-376	0	✔
HG-14-10-04	0	✔

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Ascrinvacumab (Anti-ACVRL1 / ALK-1) is a human IgG2 monoclonal antibody targeting ALK-1. It can be used for the treatment of hepatocellular carcinoma (HCC), in patients with advanced solid tumors. It also demonstrates its use in antiangiogenic therapy. MW : 150 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1463459-96-2
Molecular Weight	150 kDa
Isotype	Human IgG2SA
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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