Print

Download

Adagrasib (MRTX849) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

  • Product Name: Adagrasib (MRTX849)
  • Catalog Number: S8884
  • CAS Number: 2326521-71-3
  • IUPAC Name: 2-Piperazineacetonitrile, 4-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2S)-

Relevant identified uses and uses advised against

  • Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
  • Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

  • Company : Selleck Chemicals
  • TollFree : +1 877 796-6397
  • Tel : +1 832 582-8158
  • Fax : +1 832 582-8590

Emergency telephone number

  • Emergency phone #: +1 832 582-8158

2. Hazard(s) identification

The substance is classified and labeled according to the Globally Harmonized System (GHS).

Classification of the substance or mixture:

  • Acute toxicity - oral 4 H302: Harmful if swallowed.
  • Skin irritation 2 H315: Causes skin irritation.
  • Eye irritation 2A H319: Causes serious eye irritation.
  • Specific target organ toxicity (single exposure) 3 H335: May cause respiratory irritation.

Pictogram: GHS07
Signal word: Warning

Hazard statements:

  • H302 Harmful if swallowed.
  • H315 Causes skin irritation.
  • H319 Causes serious eye irritation.
  • H335 May cause respiratory irritation.

Precautionary statements:

  • P261 Avoid breathing powder/fume/gas/mist/vapors/spray.
  • P264 Wash thoroughly after handling.
  • P270 Do not eat, drink or smoke when using this product.
  • P271 Use only outdoors or in a well-ventilated area.
  • P280 Wear protective gloves / eye protection / face protection.
  • P301+P312 If swallowed: Call a poison center/doctor if you feel unwell.
  • P330 Rinse mouth.
  • P302+P352 If on skin: Wash with plenty of water.
  • P321 Specific treatment (see on this label).
  • P304+P340 If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P332+P313 If skin irritation occurs: Get medical advice/attention.
  • P362+P364 Take off contaminated clothing and wash it before reuse.
  • P337+P313 If eye irritation persists: Get medical advice/attention.
  • P403+P233 Store in a well-ventilated place. Keep container tightly closed.
  • P405 Store locked up.
  • P501 Dispose of contents/container in accordance with local/regional/national/international regulations.

NFPA ratings (scale 0 - 4):

  • Health = 2
  • Fire = 0
  • Reactivity = 0

HMIS-ratings (scale 0 - 4):

  • HEALTH 2: Health = 2
  • FIRE 0: Fire = 0
  • REACTIVITY 0: Reactivity = 0

Other hazards:

  • Results of PBT and vPvB assessment: PBT: Not applicable; vPvB: Not applicable.
  • Classification according to (d)(1)(ii) of § 1910.1200: The SDS issuer does not object to the classifications provided by importers or manufacturers of precursor products.
  • Hazards not otherwise classified: There are no adverse physical or health effects known that are not covered by the hazard classes of the Hazard Communications Standard.

3. Composition/information on ingredients

Chemical characterization: Substances
CAS No. Description: 2326521-71-3 2-Piperazineacetonitrile, 4-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2S)-

4. First-aid measures

Description of first aid measures:

  • General information: Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident is recommended.
  • After inhalation: In case of unconsciousness place patient stably in side position for transportation.
  • After skin contact: Immediately wash with water and soap and rinse thoroughly.
  • After eye contact: Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.
  • After swallowing: Immediately call a doctor.

Most important symptoms and effects, both acute and delayed: No further relevant information available.

Indication of any immediate medical attention and special treatment needed: No further relevant information available.

5. Fire-fighting measures

Extinguishing media:

  • Suitable extinguishing agents: Use fire fighting measures that suit the environment. A solid water stream may be inefficient.

Special hazards arising from the substance or mixture: No further relevant information available.

Advice for firefighters:

  • Protective equipment: No special measures required.

6. Accidental release measures

Personal precautions, protective equipment and emergency procedures: Not required.

Environmental precautions: Do not allow to enter sewers/ surface or ground water.

Methods and material for containment and cleaning up: Ensure adequate ventilation.

Reference to other sections:

  • See Section 7 for information on safe handling.
  • See Section 8 for information on personal protection equipment.
  • See Section 13 for disposal information.

Protective Action Criteria for Chemicals:

  • PAC-1: Substance is not listed.
  • PAC-2: Substance is not listed.
  • PAC-3: Substance is not listed.

7. Handling and storage

Precautions for safe handling:

  • No special precautions are necessary if used correctly.
  • Avoid breathing powder/fume/gas/mist/vapours/spray.
  • Avoid prolonged or repeated exposure.
  • Keep away from sources of ignition.
  • Take precautionary measures against static discharge.

Information about protection against explosions and fires: No special measures required.

Conditions for safe storage, including any incompatibilities:

  • Keep container tightly closed.
  • Store in accordance with information listed on the product insert.
  • Requirements to be met by storerooms and receptacles: No special requirements.
  • Information about storage in one common storage facility: Not required.
  • Further information about storage conditions: Keep receptacle tightly sealed.

Specific end use(s): No further relevant information available.

8. Exposure controls/personal protection

Control parameters:

  • Components with limit values that require monitoring at the workplace: Not required.
  • Additional information: The lists that were valid during the creation were used as basis.

Exposure controls:

  • Appropriate engineering controls: No further data; see section 7.

Personal protective equipment:

  • General protective and hygienic measures: Keep away from foodstuffs, beverages and feed. Immediately remove all soiled and contaminated clothing. Wash hands before breaks and at the end of work. Avoid contact with the eyes and skin.
  • Breathing equipment: In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air.
  • Protection of hands: Protective gloves. The glove material has to be impermeable and resistant to the product/ the substance/ the preparation. Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation.
  • Material of gloves: The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer.
  • Penetration time of glove material: The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.
  • Eye protection: Tightly sealed goggles.

9. Physical and chemical properties

Information on basic physical and chemical properties:

  • Physical state: powder
  • Color: Not determined.
  • Odor: Characteristic
  • Structural Formula: C32H35ClFN7O2
  • Molecular Weight: 604.1 g/mol
  • Storage Buffer: No specific data provided for this section.
  • Odor threshold: Not determined.
  • Formulation: No specific data provided for this section.
  • Melting point/Melting range: Undetermined.
  • Boiling point/Boiling range: Undetermined.
  • Flammability: Product is not flammable.
  • Explosion limits: Lower: Not determined; Upper: Not determined.
  • Flash point: Not applicable.
  • Decomposition temperature: Not determined.
  • pH-value: Not applicable.
  • Viscosity: Kinematic: Not applicable; Dynamic: Not applicable.
  • SOLUBILITY: DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml; DMSO: 1 mg/ml
  • Solubility in / Miscibility with Water: Not determined.
  • Partition coefficient (n-octanol/water): Not determined.
  • Vapor pressure: Not applicable.
  • Density: Not determined.
  • Relative density: Not determined.
  • Vapor density: Not applicable.
  • Particle characteristics: Not determined.
  • Appearance: Form: powder
  • Ignition temperature: Not determined.
  • Danger of explosion: Product does not present an explosion hazard.
  • Evaporation rate: Not applicable.

10. Stability and reactivity

Reactivity: No further relevant information available.

Chemical stability:

  • Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.

Possibility of hazardous reactions: No dangerous reactions known.

Conditions to avoid: No further relevant information available.

Incompatible materials: No further relevant information available.

Hazardous decomposition products: carbon oxides, hydrogen chloride, hydrogen fluoride, nitrogen oxides

11. Toxicological information

Information on toxicological effects:

  • Acute toxicity: No specific data provided for this section.
  • Primary irritant effect:
    • on the skin: Irritant to skin and mucous membranes.
    • on the eye: Irritating effect.
  • Sensitization: No sensitizing effects known.
  • Interactive effects: No interactive effects between components are known.

Carcinogenic categories:

  • IARC (International Agency for Research on Cancer): Substance is not listed.
  • NTP (National Toxicology Program): Substance is not listed.
  • OSHA-Ca (Occupational Safety & Health Administration): Substance is not listed.

Alternative sources for toxicological information: No non-standard sources for toxicological information where used.

12. Ecological information

Toxicity:

  • Aquatic toxicity: No further relevant information available.

Persistence and degradability: No further relevant information available.

Bioaccumulative potential: No further relevant information available.

Mobility in soil: No further relevant information available.

Results of PBT and vPvB assessment:

  • PBT: Not applicable.
  • vPvB: Not applicable.

Other adverse effects:

  • Additional ecological information:
    • General notes: Water hazard class 1 (Self-assessment): slightly hazardous for water. Do not allow undiluted product or large quantities of it to reach ground water, water course or sewage system.

13. Disposal considerations

Waste treatment methods:

  • Recommendation: Must not be disposed

16. OTHER INFORMATION

Revision Date: 2026/07/10
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.

Jump to: