Molecular Weight: 604.12 g/mol
Chemical Structure
Check the
Adagrasib (MRTX849)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(165.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(165.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(165.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(165.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(165.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
| IUPAC Name | 2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile | |
|---|---|---|
| CAS Number | 2326521-71-3 | |
| Molecular Formula |
C32H35ClFN7O2 |
|
| Molecular Weight (MW) | 604.12 | |
| SMILES | CN1CCCC1COC2=NC3=C(CCN(C3)C4=CC=CC5=C4C(=CC=C5)Cl)C(=N2)N6CCN(C(C6)CC#N)C(=O)C(=C)F | |
| InChIKey | PEMUGDMSUDYLHU-ZEQRLZLVSA-N |
- Adagrasib (MRTX849) Mechanism of Action: KRAS G12C Inhibition in Lung Adenocarcinoma Cell Research
- Adagrasib (MRTX849) Clinical Trials
- Adagrasib (MRTX849): Selectivity & Specificity
- Adagrasib (MRTX849) Working Concentration | Cell Culture | Treatment
- Adagrasib (MRTX849) Solubility in DMSO
- Adagrasib (MRTX849) Stock Solution
- Adagrasib (MRTX849) Storage
- Adagrasib (MRTX849) Stability
- Adagrasib (MRTX849) Combination Database
- Adagrasib (MRTX849) SMILES
- Adagrasib (MRTX849) CAS Number
- Adagrasib (MRTX849) Chemical Structure (2D and 3D)
- Adagrasib (MRTX849) IC50 for Cell-based and Cell-free Assays
- Adagrasib (MRTX849) Sigma (AMBH93E4C288)? Try a better option.
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- Adagrasib (MRTX849) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.