Cell-free Assays (IC50/Ki) for Adagrasib (MRTX849)

Key TargetIC50 (Cell-free)DescriptionReference
No published data available.

Cell-based Assay (IC50) for Adagrasib (MRTX849)

Cell TypeIC50 (Cell-based)DescriptionReference
MDCK-MDR cells 980 nmol/L (for P-gp inhibition) Cell permeability assay PMC9662862
Not specified (cellular mechanistic assay) 5 nmol/L pERK assay PMC9662862
LLC46 375 nM MTT assay Download PDF
Cancer cell lines 5 nM Inhibition of KRAS-dependent signal transduction and cancer cell viability PMC9362872
NCI-H358 116.9 nM CCK-8 assay, variable slope analysis in GraphPad Prism PMC11748609
Check the Adagrasib (MRTX849) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

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