Molecular Weight: 506.59 g/mol
Chemical Structure
Check the
Abemaciclib (LY2835219)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 8 mg/mL |
| DMSO |
6 mg/mL
(11.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| DMSO |
10 mg/mL
(19.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
| Ethanol | 11 mg/mL |
| DMSO |
4 mg/mL
(7.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | 10 mg/mL |
| DMSO |
3 mg/mL
(5.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | 13 mg/mL |
| DMSO |
2 mg/mL
(3.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
| IUPAC Name | N-[5-[(4-ethylpiperazin-1-yl)methyl]-2-pyridinyl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine | |
|---|---|---|
| CAS Number | 1231929-97-7 | |
| Molecular Formula |
C27H32F2N8 |
|
| Molecular Weight (MW) | 506.59 | |
| SMILES | CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F | |
| InChIKey | UZWDCWONPYILKI-UHFFFAOYSA-N |
- Abemaciclib (LY2835219) Mechanism of Action: CDK4/6 Inhibition in Breast Cancer Cell Research
- Abemaciclib (LY2835219) Clinical Trials
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- Abemaciclib (LY2835219) Working Concentration | Cell Culture | Treatment
- Abemaciclib (LY2835219) Solubility in DMSO
- Abemaciclib (LY2835219) Stock Solution
- Abemaciclib (LY2835219) Storage
- Abemaciclib (LY2835219) Stability
- Abemaciclib (LY2835219) Combination Database
- Abemaciclib (LY2835219) SMILES
- Abemaciclib (LY2835219) CAS Number
- Abemaciclib (LY2835219) Chemical Structure (2D and 3D)
- Abemaciclib (LY2835219) IC50 for Cell-based and Cell-free Assays
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- Abemaciclib (LY2835219) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.