Abemaciclib is an ATP-competitive CDK4/6 inhibitor. It blocks Rb signaling by reducing Rb phosphorylation, halting cell growth.
Abemaciclib (LY2835219) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Abemaciclib (LY2835219) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.