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Abemaciclib is an ATP-competitive CDK4/6 inhibitor. It blocks Rb signaling by reducing Rb phosphorylation, halting cell growth.
Abemaciclib (LY2835219): Mechanism of Action
Abemaciclib (LY2835219) MOA：Targeting CDK4/6 / Rb-E2F Pathway for Early and Metastatic Breast Cancer