Clinical Trials

Progesterone has been evaluated in numerous clinical trials spanning Early Phase 1 through Phase 4, investigating diverse reproductive, gynecological, and endocrine conditions including female infertility, endometriosis, uterine leiomyoma, primary dysmenorrhea, and premature birth. Sponsored by academic medical centers and government institutes, these studies encompass completed, active, and upcoming protocols. Research across this landscape evaluates key therapeutic mechanisms, ranging from receptor modulation in leiomyoma to ovarian function in patients with poor ovarian response.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06851754 RECRUITING
Premature Ovarian Insufficiency
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 2025-07-17 PHASE3
NCT07488949 RECRUITING
Chronic Endometritis
Fang Wang
 2024-04-09
NCT07738068 NOT_YET_RECRUITING
Infertility; Female Infertility; Subfertility; Infertility Primary; Infertility Secondary; Subfertility, Female
Simone Broer
 2026-08-01 PHASE3
NCT07436793 RECRUITING
Endometrial Endometrioid Adenocarcinoma; Endometrial Hyperplasia
New Mexico Cancer Research Alliance
 2026-06-15 PHASE2
NCT06572761 NOT_YET_RECRUITING
Previable Labour With Intact Membranes
Assistance Publique - Hôpitaux de Paris
 2026-09 PHASE3
NCT07613528 NOT_YET_RECRUITING
Pregnancy; Progesterone Supplementation; Low Serum Progesterone
University Hospital, Montpellier
 2027-03 PHASE3
NCT06549855 RECRUITING
Endometrial Cancer; Endometrioid Carcinoma; Mismatch Repair Deficiency
Peking University People's Hospital
 2024-09-02
NCT07508657 NOT_YET_RECRUITING
Infertility
Kirstine Kirkegaard
 2026-04 PHASE4
NCT05787509 RECRUITING
Preterm Birth
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
 2023-04-01 PHASE4
NCT07372495 RECRUITING
Preterm
National Hospital of Obstetrics and Gynecology
 2026-04-10
NCT07620587 RECRUITING
Energy Balance; Physiology - Regulation of Appetite and Food Intake
Wilfrid Laurier University
 2026-06-01
NCT07448597 RECRUITING
Preeclampsia; Hypertensive Disorder of Pregnancy
Medical University of South Carolina
 2026-08-13 PHASE4
NCT07340827 RECRUITING
Infertility
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
 2026-02-04 PHASE3
NCT06610305 RECRUITING
Major Depressive Disorder
University of North Carolina, Chapel Hill
 2024-09-02 PHASE4
NCT07608562 NOT_YET_RECRUITING
Cervical Insufficiency
Wake Forest University Health Sciences
 2026-09 PHASE4
NCT07568574 ENROLLING_BY_INVITATION
Safety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite Athletes
Enhanced Emirates Limited
 2026-03-12
NCT05555121 SUSPENDED
Fertility Issues; Embryo Implantation; Frozen Embryo Transfer
Clinique Ovo
 2022-12-01 PHASE2
NCT07434128 RECRUITING
Mammography Screening; Breast Density
OHSU Knight Cancer Institute
 2026-08-21 PHASE2
NCT07415070 NOT_YET_RECRUITING
Preterm Birth
Ningbo University
 2026-03
NCT06856174 RECRUITING
HIV Infection; Menopause
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
 2026-04-09 PHASE4
NCT06644794 RECRUITING
Infertility, Female
Shandong University of Traditional Chinese Medicine
 2025-03-05 PHASE3
NCT07714070 NOT_YET_RECRUITING
Endometrial Neoplasms; Endometrial Cancer; Atypical Endometrial Hyperplasia; Progestin Resistance
Peking University People's Hospital
 2026-07 PHASE2
NCT04783857 RECRUITING
Smoking; Smoking Cessation; Smoking Reduction
University of Minnesota
 2022-04-14 PHASE4
NCT07305519 RECRUITING
Preterm Labor
University of Roma La Sapienza
 2026-04-01
NCT05247268 RECRUITING
Endometrial Neoplasm Malignant Stage I
Fudan University
 2022-03-11 PHASE2
NCT06870266 NOT_YET_RECRUITING
Ivf; Frozen Embryo Transfer (FET)
Shaare Zedek Medical Center
 2025-03 EARLY_PHASE1
NCT04052555 ACTIVE_NOT_RECRUITING
Bilateral Breast Carcinoma; HER2-Negative Breast Carcinoma; Localized Breast Carcinoma; Recurrent Breast Carcinoma; Triple-Negative Breast Carcinoma
National Cancer Institute (NCI)
 2020-09-24 PHASE1
NCT06807580 RECRUITING
Transgender Women
Emory University
 2025-05-12 PHASE2
NCT07425990 NOT_YET_RECRUITING
Infertility Female; Frozen Embryo Transfer (FET)
University of Novi Sad
 2026-02
NCT06631547 NOT_YET_RECRUITING
Severe Head Trauma
Assiut University
 2025-12-01 PHASE1
NCT05704036 RECRUITING
Cystic Fibrosis; Hypoestrogenism
Johns Hopkins University
 2023-05-02 PHASE4
NCT05980091 SUSPENDED
Infertility; Fertility Issues; Infertility, Female
ART Fertility Clinics LLC
 2023-09-22 PHASE1
NCT03637062 NOT_YET_RECRUITING
High Risk Pregnancy
QH Medical Technology Ltd.
 2024-12-01
NCT07350317 NOT_YET_RECRUITING
Assisted Reproductive Techniques
Trust Fertility Clinic
 2026-01 PHASE4
NCT06896617 RECRUITING
Infertilities; Embryo Transfer
Fundacion Clinic per a la Recerca Biomédica
 2025-02-01 PHASE4
NCT07466199 NOT_YET_RECRUITING
Ovulation; Ovarian Function; Assisted Reproductive Treatments; Oocyte Maturation; Hormonal Response
Instituto Valenciano de Infertilidade de Lisboa
 2026-07 PHASE4
NCT07136922 RECRUITING
Luteal Phase Insuffiency; Progesterone Delivery
Calla Lily Clinical Care Ltd
 2026-04-20 PHASE1
NCT07162961 NOT_YET_RECRUITING
Adenomyosis of Uterus
Sun Yat-sen University
 2025-09-01 PHASE3
NCT06904274 WITHDRAWN
Endometrial Hyperplasia
Bayer
 2025-11-24 PHASE3
NCT07242131 RECRUITING
Polycystic Ovary Syndrome (PCOS)
Ege University
 2025-12-01
NCT07649668 COMPLETED
Preterm Labor
Dr Mudassar Saeed Pansota
 2025-11-30 PHASE4
NCT05969795 RECRUITING
Pregnancy Related; Infertility, Female
ART Fertility Clinics LLC
 2023-09-05 PHASE1
NCT05951400 COMPLETED
IVF; PCO
Beni-Suef University
 2024-01-01 PHASE2; PHASE3
NCT06975943 COMPLETED
Pregnant Women; Pregnancies at Increased Risk of Preterm Birth
Dr. Soetomo General Hospital
 2025-01-01
NCT04549116 COMPLETED
Infertility
IBSA Institut Biochimique SA
 2022-10-12 PHASE3
NCT03740204 ACTIVE_NOT_RECRUITING
Eating Disorders; Hypoestrogenemia
Massachusetts General Hospital
 2019-06-13 PHASE2
NCT07495007 COMPLETED
Bioequivalance; Post-menopause
Zi Diligence Biocenter
 2025-11-10 PHASE1
NCT05080569 RECRUITING
Pregnancy Related; Fertility Issues; Luteal Phase Defect; Infertility Unexplained
UMC Utrecht
 2023-03-01 PHASE4
NCT05365464 WITHDRAWN
Recurrent Pregnancy Loss Without Current Pregnancy
Wake Forest University Health Sciences
 2022-05 PHASE2
NCT07523295 COMPLETED
Preterm Labor With Intact Membranes; Preterm Birth
Medicare Hospital (Pvt) Limited
 2025-05-06 PHASE4
NCT02633878 COMPLETED
Threatened Miscarriage
Heilongjiang University of Chinese Medicine
 2017-10-20 PHASE3
NCT03068910 RECRUITING
Hyperandrogenism; Polycystic Ovary Syndrome; Puberty
University of Virginia
 2016-07-21 EARLY_PHASE1
NCT04597099 UNKNOWN
PCOS; Polycystic Ovary Syndrome
University of Virginia
 2022-10-26 EARLY_PHASE1
NCT00929006 RECRUITING
Puberty; Hyperandrogenism
University of Virginia
 2008-06 EARLY_PHASE1
NCT05997563 UNKNOWN
Preterm Labor
Chulalongkorn University
 2023-08-16 PHASE4
NCT07264933 COMPLETED
Scar Niche; Myometrial Remodeling; Contraceptive Device; Complications; Cesarean Section Complications
Benha University
 2025-02-12
NCT06928844 RECRUITING
Low Dose; Progesterone; Triggering Ovulation
The General Authority for Teaching Hospitals and Institutes
 2025-04-15
NCT01425541 UNKNOWN
Hyperandrogenemia; Polycystic Ovary Syndrome (PCOS)
University of Virginia
 2000-04
NCT04725864 UNKNOWN
Infertility; Embryo Transfer
Vastra Gotaland Region
 2021-05-01 PHASE4
NCT06637189 NOT_YET_RECRUITING
Stimulation in the Ovary; Embryo; Oocyte; Oocyte Retrieval; Fertilization in Vitro; Blastocyst; PGT-A
Ginefiv
 2024-10-15 PHASE4
NCT05982470 UNKNOWN
Cerebral Small Vessel Diseases; Postmenopausal Symptoms; Mild Cognitive Impairment; White Matter Hyperintensity
Beijing Tiantan Hospital
 2023-08-18 PHASE2
NCT04499131 COMPLETED
Infertility, Female; ENDOMETRIAL RECEPTIVITY
Instituto Valenciano de Infertilidad, IVI VALENCIA
 2021-12-09 PHASE4
NCT04675788 COMPLETED
Long QT Syndrome; Abnormalities, Drug-Induced
Indiana University
 2021-09-02 PHASE4
NCT05954962 COMPLETED
IVF
Instituto Bernabeu
 2023-12-23 PHASE4
NCT04719273 COMPLETED
Refractory Endometrial Adenocarcinoma; Refractory Endometrial Carcinoma; Refractory Endometrial Clear Cell Adenocarcinoma; Refractory Endometrial Endometrioid Adenocarcinoma; Refractory Endometrial Mixed Cell Adenocarcinoma; Refractory Endometrial Serous Adenocarcinoma; Refractory Endometrial Undifferentiated Carcinoma
Thomas Jefferson University
 2021-01-28 PHASE2
NCT04806919 COMPLETED
IVF; Embryo Loss; Luteal Phase Defect
University Hospital, Ghent
 2021-04-02 PHASE3
NCT05838105 UNKNOWN
Luteal Phase Support
Shaare Zedek Medical Center
 2022-10-01
NCT03976544 TERMINATED
Miscarriage; Frozen Embryo Transfer; Natural Cycle; Hormone Replacement Therapy Cycle; Preimplantation Genetic Screening; Euploid Embryos
CRG UZ Brussel
 2019-05-25 PHASE4
NCT06005207 UNKNOWN
Infertility, Female
Nanjing University
 2023-08-01
NCT05091866 TERMINATED
Gliosarcoma; Recurrent Glioblastoma
Emory University
 2022-04-11 EARLY_PHASE1
NCT02518594 COMPLETED
Short Cervical Length
The George Washington University Biostatistics Center
 2015-11-13 PHASE3
NCT05780489 UNKNOWN
Infertility, Female; Reproductive Sterility
Instituto Valenciano de Infertilidad, IVI VALENCIA
 2023-04-14
NCT05987657 COMPLETED
Infertility
Hospices Civils de Lyon
 2023-11-15
NCT03642665 COMPLETED
Embryo Transfer
Universitaire Ziekenhuizen KU Leuven
 2018-09-25 PHASE4
NCT00001481 COMPLETED
Postpartum Depression
National Institute of Mental Health (NIMH)
 1996-04-26 PHASE2
NCT05767086 COMPLETED
Infertility
Bezmialem Vakif University
 2023-03-15
NCT03909152 COMPLETED
Granulosa Cell Ovarian Cancer; Low Grade Serous Ovarian/ Primary Peritoneal Cancer; Endometrioid Endometrial Cancer
Memorial Sloan Kettering Cancer Center
 2019-05-02 PHASE2
NCT07319715 COMPLETED
Twin Pregnancy With Antenatal Problem
Benha University
 2023-01-20 PHASE2
NCT04112368 COMPLETED
Suicidal Ideation
University of Illinois at Chicago
 2020-09-15 PHASE4
NCT05565573 UNKNOWN
Fertility Sparing
Hua Li
 2022-11-01 PHASE2; PHASE3
NCT06089395 Not yet recruiting
Poor Ovarian Response
Shi Yun|Capital Medical University|Dongzhimen Hospital Beijing
 2024-06-01 Early Phase 1
NCT05128071 COMPLETED
Methamphetamine-dependence; Postpartum Abstinence
University of Utah
 2022-02-04 EARLY_PHASE1
NCT04897269 UNKNOWN
Assisted Reproductive Technology
Tu Du Hospital
 2021-05-20 PHASE3
NCT06359457 Not yet recruiting
Primary Dysmenorrhea
Cairo University
 2024-05 --
NCT06334315 Not yet recruiting
Contraception|Pharmacogenomic Drug Interaction
Yale University|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 2024-05 Phase 4
NCT05227456 WITHDRAWN
Abnormal Uterine Bleeding; Dysmenorrhea
Saskatchewan Health Authority - Regina Area
 2022-07-01 PHASE2
NCT03251729 COMPLETED
Premature Birth
Thomas Jefferson University
 2017-09-22 PHASE4
NCT04209543 COMPLETED
Vasomotor Symptoms; Menopausal Symptoms
Estetra
 2019-12-30 PHASE3
NCT05232344 COMPLETED
Infertility
University Hospital, Montpellier
 2022-04-13
NCT04695483 COMPLETED
Infertility
IRCCS San Raffaele
 2022-02-22 PHASE4
NCT06297564 COMPLETED
Progesterone Primed Endometrial Protocol; Gonadotropin Releasing Hormone Antagonist Protocol; Assisted Reproductive Treatments
New Valley University
 2022-09-01
NCT05319834 COMPLETED
Preterm Birth
Menoufia University
 2022-04-01 PHASE4
NCT06091436 COMPLETED
Infertility
Changchun GeneScience Pharmaceutical Co., Ltd.
 2023-03-24 PHASE3
NCT05481684 UNKNOWN
Infertility; IVF; Progesterone
Bezmialem Vakif University
 2022-08-08
NCT05511272 COMPLETED
Fertility Disorders
Universitair Ziekenhuis Brussel
 2022-08-15
NCT05758064 UNKNOWN
Hormonal Replacement Frozen Embryo Transfer Cycle
El Shatby University Hospital for Obstetrics and Gynecology
 2023-01-01 PHASE2; PHASE3
NCT02673359 UNKNOWN
Premature Labour
Mohamed Sayed Abdelhafez
 2016-02 PHASE4
NCT06938711 WITHDRAWN
Breast Cancer
Context Therapeutics Inc.
 2023-06 PHASE1; PHASE2
NCT05112692 UNKNOWN
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Mansoura University
 2021-11
NCT05286554 COMPLETED
Female Infertility
Alexandria University
 2022-03-17 PHASE4
NCT05542797 UNKNOWN
Miscarriage Threatening
Konya Meram State Hospital
 2022-10 PHASE4
NCT05505435 COMPLETED
Contraception
Northwestern University
 2022-08-01 PHASE4
NCT04758871 COMPLETED
Frozen Embryo Transfer; Hormone Replacement Therapy; Dydrogesterone; Infertility, Female
CRG UZ Brussel
 2021-10-01 PHASE4
NCT04910711 UNKNOWN
Human Immunodeficiency Virus; Contraception; ART
Botswana Harvard AIDS Institute Partnership
 2021-10-21 PHASE4
NCT03863613 TERMINATED
Preterm Birth; Twin Pregnancy; Short Cervix
Mỹ Đức Hospital
 2019-03-23
NCT05618613 TERMINATED
Breast Cancer
Context Therapeutics Inc.
 2022-12-02 PHASE1; PHASE2
NCT05973253 COMPLETED
Photorefractive Keratectomy
Isfahan University of Medical Sciences
 2023-04-21 PHASE2; PHASE3
NCT04190927 UNKNOWN
Menopause; Perimenopausal Disorder; Menopause Related Conditions
Women's Hormone Network
 2020-06-01 PHASE4
NCT04938011 UNKNOWN
Infertility
Nanjing University
 2021-07 PHASE2
NCT04460807 TERMINATED
Ovarian Cancer
Ente Ospedaliero Ospedali Galliera
 2020-02-13 PHASE3
NCT06616077 COMPLETED
Endometrial Endocrine Regulation; Progesterone Supplementation in Women After Mifepristone
Reproductive Health Research Insritute, Chile
 2022-06-07 EARLY_PHASE1
NCT05161338 COMPLETED
Infertility, Female
Instituto Valenciano de Infertilidad, IVI VALENCIA
 2022-02-15
NCT02430233 COMPLETED
Preterm Labor
HaEmek Medical Center, Israel
 2018-12-19 PHASE4
NCT03018366 COMPLETED
Estrogen Deficiency; Cardiovascular Disease (CVD); Functional Hypothalamic Amenorrhea; Endothelial Dysfunction
Cedars-Sinai Medical Center
 2017-01-01 PHASE2
NCT04534881 TERMINATED
Transgender Persons
St. Louis University
 2020-10-20 PHASE2
NCT05367973 COMPLETED
Vulvovaginal Atrophy; Vasomotor Symptoms
Daré Bioscience, Inc.
 2022-04-11 PHASE1; PHASE2
NCT05312190 UNKNOWN
Menstrual Disorders
Peking Union Medical College Hospital
 2022-03-15
NCT02511574 COMPLETED
Preterm Labor; Premature Birth
University of Sao Paulo
 2015-08-03 PHASE4
NCT05491343 UNKNOWN
Arteriovenous Malformations
HaEmek Medical Center, Israel
 2022-08 PHASE4
NCT03729869 COMPLETED
Cannabis Use
Medical University of South Carolina
 2019-01-18 PHASE2
NCT04414761 COMPLETED
IVF; GnRH Antagonist; PPOS
ShangHai Ji Ai Genetics & IVF Institute
 2020-06-04 PHASE3
NCT03227705 COMPLETED
Preterm Birth; Short Cervix
Université de Sherbrooke
 2018-06-04
NCT04342585 COMPLETED
Preterm Birth
National University of Malaysia
 2019-10-01 PHASE3
NCT03701490 COMPLETED
Infertility
IBSA Institut Biochimique SA
 2019-03-12 PHASE2
NCT05939284 COMPLETED
PCOS
Zagazig University
 2021-06-01
NCT04128436 COMPLETED
Luteal Phase Progesterone Levels
Hacettepe University
 2019-01-01
NCT06100783 COMPLETED
Complications of DMPA Injectable Contraceptives
Assiut University
 2021-01-01
NCT04087408 UNKNOWN
Effect of Adding GnRHa as Luteal Phase Support in Antagonist ART Cycles
Moustafa Mohammed Abouelea
 2020-04-01 PHASE3
NCT04278508 COMPLETED
IVF
Hillel Yaffe Medical Center
 2020-03-09
NCT05109676 COMPLETED
IVF
University Hospital, Toulouse
 2021-12-07
NCT05276531 COMPLETED
Progesterone
Bezmialem Vakif University
 2022-04-01
NCT04161989 COMPLETED
Small for Gestational Age at Delivery
Assiut University
 2020-05-01
NCT04874285 COMPLETED
Pregnancy, High Risk
Lo.Li.Pharma s.r.l
 2021-05-03
NCT05184777 COMPLETED
Infertility, Female; Reproductive Sterility
Instituto Valenciano de Infertilidad, IVI VALENCIA
 2022-02-03
NCT05484193 UNKNOWN
Use of GnRH Agonist Alone for Luteal Phase Support in Fresh IVF Cycles
Shaare Zedek Medical Center
 2020-06-08
NCT04225221 COMPLETED
Bulimia Nervosa
University of North Carolina, Chapel Hill
 2020-02-24 PHASE2
NCT03540225 WITHDRAWN
Premature Birth; Twin Pregnancy
Chiu Yee Liona Poon
 2020-04 PHASE3
NCT04300322 UNKNOWN
Preterm Birth; Short Cervix
Mỹ Đức Hospital
 2020-05-01
NCT04654741 UNKNOWN
IVF; Infertility
Casa di Cura Privata Villa Mafalda
 2020-09-01 PHASE4
NCT04710017 COMPLETED
Uterine Bleeding
Assiut University
 2021-02-01
NCT04753957 TERMINATED
Pregnancy Related
Thomas Jefferson University
 2022-01-07 PHASE1
NCT01898312 COMPLETED
Women With Mutations in the Breast Cancer Susceptibility Genes BRCA1,2
Karolinska Institutet
 2013-09 PHASE2
NCT03781674 UNKNOWN
Twin; Pregnancy, Affecting Fetus or Newborn
Aswan University Hospital
 2019-01-01
NCT03948022 COMPLETED
Implantation; Placenta; Pregnancy Loss; Frozen Embryo; Luteal Support; Luteal Phase Defect; Assisted Reproduction
Centrum Clinic IVF Center
 2021-06-30 PHASE4
NCT01954966 COMPLETED
Nicotine Dependence; Nicotine Withdrawal
University of Pennsylvania
 2010-11 PHASE4
NCT02133573 COMPLETED
Congenital Heart Disease; Periventricular Leucomalacia; Brain Development; Cardiac Surgery; Neurodevelopmental Disability; Fetal Neuroprotection
Children's Hospital of Philadelphia
 2014-07 PHASE2
NCT04077853 COMPLETED
Preeclampsia
Assiut University
 2019-12-15 PHASE4
NCT04046185 UNKNOWN
Endometrial Cancer Stage I
Shanghai First Maternity and Infant Hospital
 2019-10-01 EARLY_PHASE1
NCT04797338 UNKNOWN
Pregnancy Early; Miscarriage; Ovarian Hyperstimulation Syndrome
Assaf-Harofeh Medical Center
 2017-12-29 PHASE4
NCT04104984 UNKNOWN
Preterm Labour
Assiut University
 2020-02-15 EARLY_PHASE1
NCT02187224 COMPLETED
Alcohol Dependence; Post-Traumatic Stress Disorder (PTSD)
Yale University
 2016-09-01 PHASE2; PHASE3
NCT03619707 COMPLETED
Sterility; Infertility
American University of Beirut Medical Center
 2018-08-01 PHASE4
NCT02913495 COMPLETED
Premature Birth
Thomas Jefferson University
 2016-09 PHASE4
NCT00468715 COMPLETED
Breast Cancer
Memorial Sloan Kettering Cancer Center
 2007-03-23 PHASE2
NCT03433040 COMPLETED
Premature Birth; Absorption; Chemicals
University of South Florida
 2017-08-23 PHASE3
NCT04140968 TERMINATED
Menopause; Progesterone; Weight Gain
Insel Gruppe AG, University Hospital Bern
 2019-11-01 PHASE4
NCT02449161 TERMINATED
Menorrhagia
Guy Waddell
 2015-08 PHASE3
NCT05418426 COMPLETED
Vulvovaginal Atrophy; Vasomotor Symptoms
Daré Bioscience, Inc.
 2020-08-18 PHASE1
NCT05143723 UNKNOWN
Infertility
Kuban State Medical University
 2020-01-20 PHASE2
NCT05189145 COMPLETED
Female Infertility
Alexandria University
 2019-10-01
NCT04537078 COMPLETED
Infertility, Female
El Shatby University Hospital for Obstetrics and Gynecology
 2020-09-01 PHASE3
NCT02145767 COMPLETED
Miscarriage; Preterm Birth
Sir Mortimer B. Davis - Jewish General Hospital
 2014-12 PHASE2
NCT03998761 COMPLETED
Infertility
Mỹ Đức Hospital
 2019-06-26
NCT03428685 UNKNOWN
Preterm Birth
The University of Hong Kong
 2019-01-15 PHASE2; PHASE3
NCT03992937 COMPLETED
Endometrial Hyperplasia Without Atypia
Kocaeli University
 2019-06-20
NCT02460302 WITHDRAWN
Atrophic Vaginitis; Menopause; Vulvovaginal Atrophy
Mount Sinai Hospital, Canada
 2016-12 PHASE2
NCT04143880 UNKNOWN
Stroke
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2020-02-01 PHASE4
NCT03395756 COMPLETED
Emergency Contraception; Contraception
University of Southern California
 2018-08-31 EARLY_PHASE1
NCT04807543 COMPLETED
Preterm Premature Rupture of Membrane
Ain Shams University
 2018-01-10 PHASE2
NCT04365127 COMPLETED
COVID-19; Sars-CoV2
Sara Ghandehari
 2020-04-27 PHASE1
NCT04748562 COMPLETED
Twin Pregnancy With Antenatal Problem
Ain Shams University
 2020-01-01 PHASE4
NCT03297216 COMPLETED
Pre-term Birth; HIV-1-infection
University of North Carolina, Chapel Hill
 2018-02-07 PHASE3
NCT01265017 WITHDRAWN
Type 1 Diabetes
Sansum Diabetes Research Institute
 2012-07 PHASE1
NCT00123669 COMPLETED
Breast Neoplasms
Tata Memorial Hospital
 1997-10 PHASE2; PHASE3
NCT03003949 TERMINATED
Perimenopausal Disorder; Stress, Emotional
University of North Carolina, Chapel Hill
 2017-01-24 PHASE4
NCT00001322 COMPLETED
Healthy Volunteers
National Institute of Mental Health (NIMH)
 1994-06-09 PHASE1; PHASE2
NCT03740568 COMPLETED
Infertility; Progesterone; Frozen Embryo Transfer; Euploid Embryo Transfer; Pregnancy Outcome; Artificial Cycle; Ongoing Pregnancy
Fundacion Dexeus
 2018-11-15
NCT03356964 COMPLETED
Progesterone Resistance
ART Fertility Clinics LLC
 2017-11-23 EARLY_PHASE1
NCT00946192 COMPLETED
Exercise-related Amenorrhea
Massachusetts General Hospital
 2009-05 PHASE3
NCT00594217 COMPLETED
Normal; PCOS
University of Virginia
 2007-11-29 PHASE1
NCT05125640 COMPLETED
Pharmacokinetics
Joint Stock Company "Farmak"
 2019-12-13 PHASE1
NCT03253016 UNKNOWN
Preterm Labor
Western Galilee Hospital-Nahariya
 2017-03-26
NCT04846218 COMPLETED
Infertility, Female
Ain Shams University
 2016-12
NCT03181685 TERMINATED
Infertility; In Vitro Fertilization
Andros Day Surgery Clinic
 2016-12-20 PHASE4
NCT02372942 UNKNOWN
Preterm Delivery
University of Padova
 2014-02 PHASE4
NCT02651844 COMPLETED
Breast Cancer
Hospital Provincial Magdalena V. de Martínez
 2016-04
NCT03309709 UNKNOWN
Endometrial Polyp
University Magna Graecia
 2017-10-08 PHASE3
NCT02357368 COMPLETED
HIV; Contraception
Lisa Haddad
 2015-02 PHASE4
NCT04124913 UNKNOWN
Infertility, Female; Infertility, Male; Embryo Transfer; Fertilization in Vitro; Drug Effect; Reproductive Techniques, Assisted; Progesterone; Dydrogesterone
Memorial Sisli Hospital, Istanbul
 2019-01-02 PHASE4
NCT01980680 COMPLETED
Infertility
Peter Humaidan
 2014-12 PHASE4
NCT02032797 COMPLETED
Cryopreservation; Embryo Implantation; Progesteron
Universitair Ziekenhuis Brussel
 2012-11 PHASE4
NCT03565211 COMPLETED
Progesterone Supplementation in Women Undergoing ART
Ferring Pharmaceuticals
 2018-07-26 PHASE3
NCT03774745 TERMINATED
Pregnancy, Unwanted
University of California, Davis
 2019-02-11 PHASE1; PHASE2
NCT03633175 UNKNOWN
Placenta Previa
Ain Shams University
 2018-07-05 PHASE2
NCT04008966 COMPLETED
Assisted Reproduction
Cairo University
 2016-07-20 PHASE4
NCT03737656 COMPLETED
Pharmacokinetics
Grünenthal GmbH
 2018-11-01 PHASE1
NCT03725904 COMPLETED
Infertility, Female
Peter Humaidan
 2018-10-24
NCT02846909 COMPLETED
Abortion
Assiut University
 2017-04-01 PHASE2
NCT03504345 UNKNOWN
Infertility Due to Nonimplantation; Infertility
Mount Sinai Hospital, Canada
 2018-05
NCT03734770 COMPLETED
Progesterone; Luteal Phase Support; In Vitro Fertilization
Universita di Verona
 2019-01-01
NCT03058536 UNKNOWN
Preterm Birth; Twin Pregnancy With Antenatal Problem
Mario Henrique Burlacchini de Carvalho
 2017-02-21 PHASE2; PHASE3
NCT02950948 WITHDRAWN
Luteal Phase Defect
IBSA Institut Biochimique SA
 2017-05-03 PHASE3
NCT03202186 TERMINATED
Menopause Related Conditions
BHR Pharma, LLC
 2017-08-01 PHASE3
NCT03219489 COMPLETED
Preterm Birth; Pregnancy
McMaster University
 2017-10-05
NCT02255175 COMPLETED
Perimenopausal Depression
University of North Carolina, Chapel Hill
 2015-10-01 PHASE4
NCT03687021 UNKNOWN
Endometrial Receptivity;RNA; Progesterone
Peking Union Medical College Hospital
 2018-10-10 EARLY_PHASE1
NCT01004029 COMPLETED
Preterm Birth
AMAG Pharmaceuticals, Inc.
 2009-10 PHASE3
NCT03152942 UNKNOWN
Premature Obstetric Labor
St Stephens Aids Trust
 2017-10-05 PHASE1
NCT02224313 COMPLETED
Menopause
Intira Sriprasert
 2015-12 PHASE3
NCT03202836 COMPLETED
Preterm Labor
Chulalongkorn University
 2017-06-29
NCT02470676 UNKNOWN
Preterm Birth; Short Cervix
Hillel Yaffe Medical Center
 2015-07 PHASE2; PHASE3
NCT03537287 UNKNOWN
Preterm Labor
Ain Shams University
 2016-07 PHASE2
NCT02103764 UNKNOWN
Dysfunctional Uterine Bleeding
Mahidol University
 2013-08 PHASE3
NCT01464697 COMPLETED
Hot Flushes; Night Sweats
University of British Columbia
 2011-10 PHASE3
NCT02779582 COMPLETED
Perimenopause; Menstrual Cramps
University of British Columbia
 2015-06 PHASE3
NCT01840228 TERMINATED
Premature Birth; Obstetric Labor, Premature
Washington University School of Medicine
 2013-05
NCT02950935 TERMINATED
Threatened Abortion in First Trimester
IBSA Institut Biochimique SA
 2017-04-04 PHASE3
NCT02254577 COMPLETED
Infertility
Shady Grove Fertility Reproductive Science Center
 2014-10 PHASE4
NCT03018249 COMPLETED
FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma; FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma; FIGO Grade 3 Endometrial Endometrioid Adenocarcinoma
National Cancer Institute (NCI)
 2017-10-11 EARLY_PHASE1
NCT02749344 COMPLETED
Infertility
HaEmek Medical Center, Israel
 2016-05
NCT03430050 COMPLETED
Cannabis Use Disorder; Cannabis Withdrawal
Medical University of South Carolina
 2017-10-16 EARLY_PHASE1
NCT03484611 UNKNOWN
Invitro Fertilizaion
Cairo University
 2013-01
NCT02228681 COMPLETED
Advanced, Persistent, or Recurrent Endometrial Cancer
GOG Foundation
 2015-05-21 PHASE2
NCT03071172 UNKNOWN
Ovarian Hyperstimulation Syndrome
Changchun GeneScience Pharmaceutical Co., Ltd.
 2017-03 PHASE3
NCT01940653 COMPLETED
Progesterone Supplementation
Universitair Ziekenhuis Brussel
 2012-11 PHASE4
NCT03309176 COMPLETED
Ovulation Disorder
Radboud University Medical Center
 2016-06-21 PHASE4
NCT02623881 COMPLETED
Pregnancy
Vietnam National University
 2016-03-04
NCT03720847 COMPLETED
Suicidal Ideation
University of North Carolina, Chapel Hill
 2016-12-31 PHASE4
NCT02598323 UNKNOWN
Premature Labour
Assistance Publique Hopitaux De Marseille
 2015-11
NCT02513940 COMPLETED
Long QT Syndrome
Indiana University
 2016-05 PHASE4
NCT02969590 COMPLETED
Fertility; Contraception
Oregon Health and Science University
 2015-03-29 PHASE4
NCT03174691 COMPLETED
Infertility
Vietnam National University
 2017-06-07
NCT02841137 COMPLETED
Menopause
IBSA Institut Biochimique SA
 2016-06 PHASE2
NCT02329535 TERMINATED
Premature Birth
HaEmek Medical Center, Israel
 2015-01
NCT01428193 TERMINATED
Polycystic Ovary Syndrome; Hyperandrogenism
University of Virginia
 2006-09
NCT01744574 COMPLETED
Tobacco Cessation
University of Minnesota
 2012-12
NCT03120715 UNKNOWN
Infertility
Nanfang Hospital, Southern Medical University
 2016-07-01 PHASE4
NCT02793908 UNKNOWN
Endometriosis
University Magna Graecia
 2016-06 PHASE3
NCT01811225 COMPLETED
Nicotine Dependence; Contraception
University of Minnesota
 2012-12 PHASE2
NCT02118051 COMPLETED
Infertility
Instituto de Investigacion Sanitaria La Fe
 2013-09 PHASE3
NCT02122198 COMPLETED
Cognitive Impairment; Executive Dysfunction; Endothelial Dysfunction; Cardiovascular Disease
University of Colorado, Denver
 2014-09-08
NCT03130504 COMPLETED
Preterm Labor
Assiut University
 2016-04-01 PHASE2
NCT01463202 COMPLETED
Contraception; Postpartum Depression; Lactation
Beatrice Chen
 2011-11 PHASE4
NCT02937766 TERMINATED
Assessing Injection Pain of Makena® (Hydroxyprogesterone Caproate Injection, 250 mg/mL) in Healthy Post-menopausal Women
AMAG Pharmaceuticals, Inc.
 2016-10-07 PHASE3
NCT02350231 COMPLETED
Preterm Birth
Assiut University
 2014-02-01 PHASE2; PHASE3
NCT01269450 TERMINATED
Antepartum Bleeding; Preterm Birth
HaEmek Medical Center, Israel
 2011-03
NCT02400021 UNKNOWN
HIV-1 Infection
Mount Sinai Hospital, Canada
 2015-08 PHASE2
NCT02940522 COMPLETED
Comparing Bioavailability When Makena® is Administered in Healthy Post-menopausal Women
AMAG Pharmaceuticals, Inc.
 2016-09 PHASE1
NCT02655146 UNKNOWN
Infertility
Chong Qing Reproducive and Genetic Institute
 2015-12 PHASE4
NCT03440359 COMPLETED
Polycystic Ovary Syndrome
Eastern Virginia Medical School
 2012-07-06 PHASE2; PHASE3
NCT03040830 COMPLETED
Progesterone Luteal Support in ICSI; Embryo Transfer
Mansoura Integrated Fertility Center
 2015-11-01 PHASE4
NCT01942668 COMPLETED
Menopause
TherapeuticsMD
 2013-08-05 PHASE3
NCT01762943 COMPLETED
Postpartum Depression
University of North Carolina, Chapel Hill
 2013-08
NCT02788097 TERMINATED
Progesterone Induced Endometrial Receptivity
Antalya IVF
 2016-05
NCT02363127 COMPLETED
Infertility
Instituto Bernabeu
 2015-02 PHASE4
NCT01941875 COMPLETED
Infertility
University of Alberta
 2014-07 PHASE3
NCT02571296 UNKNOWN
Preterm Birth
Ghamra Military Hospital
 2015-07 PHASE4
NCT01643980 COMPLETED
Early Onset of Delivery Before 37 Weeks
Dra.Cristina Martinez Payo
 2012-08 PHASE4
NCT01850030 COMPLETED
Female Infertility
Abbott
 2013-08 PHASE3
NCT02335203 UNKNOWN
Grade 1 Endometrial Endometrioid Adenocarcinoma; Grade 2 Endometrial Endometrioid Adenocarcinoma; Complex Atypical Endometrial Hyperplasia
Women and Infants Hospital of Rhode Island
 2015-02 PHASE2
NCT02262416 UNKNOWN
Infertility
Queensland Fertility Group
 2015-01 PHASE3
NCT01589081 WITHDRAWN
Nicotine Dependence
Mclean Hospital
 2008-09
NCT02492451 TERMINATED
Pregnancy
Zeynep Kamil Maternity and Pediatric Research and Training Hospital
 2015-06
NCT02567552 COMPLETED
Reproductive Techniques, Assisted
IVI Barcelona
 2015-05 PHASE4
NCT01809639 COMPLETED
Concussion
Wake Forest University Health Sciences
 2013-06 PHASE4
NCT00759642 TERMINATED
Metastatic Breast Cancer
University of Kansas Medical Center
 2009-03 PHASE2
NCT02601898 COMPLETED
Subchorionic Hematoma in the First Trimester Pregnancy; Miscarriage
Azienda USL Ferrara
 2015-01 PHASE4
NCT02078869 COMPLETED
Infertility
Toronto Centre for Advanced Reproductive Technology
 2015-05-15
NCT01602679 TERMINATED
Female Reproductive Physiology
University of Virginia
 2012-05 PHASE1
NCT01798394 COMPLETED
Tobacco Use Cessation; Tobacco Use Disorder
University of Minnesota
 2014-06
NCT00997893 COMPLETED
Menopause; Hot Flashes
University of Illinois at Chicago
 2009-12 PHASE2
NCT01599494 WITHDRAWN
Infertility
Organon and Co
 2014-03 PHASE3
NCT01670929 COMPLETED
Abortion, Habitual
Woman's Health University Hospital, Egypt
 2012-09 PHASE4
NCT02340013 COMPLETED
Infertility
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
 2013-07 PHASE4
NCT02872818 COMPLETED
Apoptotic Signal Pathways in Endometrial Hyperplasia
Kayseri Education and Research Hospital
 2014-10 PHASE4
NCT01427595 COMPLETED
Polycystic Ovary Syndrome; Hyperandrogenism
University of Virginia
 2009-02-18
NCT01780610 UNKNOWN
Infertility
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
 2012-01
NCT01780558 UNKNOWN
Infertility
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
 2010-01
NCT01147484 COMPLETED
Recurrent Breast Cancer
NCIC Clinical Trials Group
 2010-09-02 PHASE2
NCT01790282 COMPLETED
IVF; Infertility
Mansoura Integrated Fertility Center
 2013-03
NCT02019589 TERMINATED
Secondary Amenorrhea
TherapeuticsMD
 2014-01-20 PHASE3
NCT01927029 UNKNOWN
Pregnancies
Universidad del Desarrollo
 2013-08 PHASE4
NCT02338830 COMPLETED
Premature Labour
Mohamed Sayed Abdelhafez
 2012-06 PHASE4
NCT01286246 TERMINATED
Obstetric Labor, Premature
University of Calgary
 2011-01 PHASE4
NCT01863680 COMPLETED
Luteal Hormone Supplementation in In-vitro Fertilization; Embryo Transfer
Merck KGaA, Darmstadt, Germany
 2013-07 PHASE3
NCT01899846 COMPLETED
Pregnancy
Lumara Health, Inc.
 2013-07 PHASE1
NCT01207102 TERMINATED
Metastatic Breast Cancer
Duke University
 2011-08 PHASE2
NCT01929083 COMPLETED
Prolonged QT Interval in EKG and Sudden Death
Indiana University
 2013-04 PHASE2
NCT00822900 TERMINATED
Traumatic Brain Injury
David Wright
 2010-03 PHASE3
NCT01031017 COMPLETED
Preterm Delivery
University of Sao Paulo
 2007-06 PHASE4
NCT01119963 COMPLETED
Preterm Delivery
Obstetrix Medical Group
 2011-10 PHASE2; PHASE3
NCT01421368 COMPLETED
HIV Prevention
CONRAD
 2012-03 PHASE1
NCT00479674 COMPLETED
Breast Cancer
Duke University
 2007-05 PHASE2
NCT01909141 COMPLETED
Polycystic Ovary Syndrome; Infertility
Cairo University
 2013-08 EARLY_PHASE1
NCT02524561 COMPLETED
Mammographic Density; Abnormal Mammogram
Brigham and Women's Hospital
 2005-09
NCT01501890 WITHDRAWN
Threatened Abortion; Pre-Eclampsia; Abruptio Placentae; Fetal Growth Retardation; Premature Birth
Soroka University Medical Center
 2012-01
NCT01441635 COMPLETED
Heavy Uterine Bleeding; Uterine Fibroids
AbbVie (prior sponsor, Abbott)
 2011-09-08 PHASE2
NCT01178931 COMPLETED
Luteal Phase Defect
University of Zagreb
 2010-10
NCT00585520 COMPLETED
Cocaine Dependence
Yale University
 2007-09 PHASE1
NCT01493791 WITHDRAWN
Urogenital Abnormalities
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 2011-11-08 EARLY_PHASE1
NCT01249274 COMPLETED
Cocaine Abuse; Cocaine Dependence
Yale University
 2011-02
NCT01023178 COMPLETED
Ovarian Failure, Premature
Stanford University
 2007-02
NCT01888744 COMPLETED
Reproductive Endocrinology; Fertility; Optimal Stimulation Protocol
Universitair Ziekenhuis Brussel
 2010-09 PHASE4
NCT01796522 WITHDRAWN
Preterm Delivery.
Instituto de Investigacion Sanitaria La Fe
 2013-03 PHASE3
NCT00743574 COMPLETED
Polycystic Ovarian Syndrome; Vitamin D Deficiency
Yale University
 2008-08
NCT00946088 TERMINATED
Pregnancy Complications
Stanford University
 2009-10 PHASE2; PHASE3
NCT01418209 COMPLETED
Hot Flashes; Menopause; Vasomotor Disturbance
Fred Hutchinson Cancer Center
 2011-11
NCT01381016 COMPLETED
Obesity; Infertility
University of Colorado, Denver
 2011-06
NCT01225835 COMPLETED
Infertility
Ferring Pharmaceuticals
 2010-10 PHASE4
NCT00856050 COMPLETED
Leiomyosarcoma
Dana-Farber Cancer Institute
 2009-02 PHASE2
NCT00141908 COMPLETED
Preterm Delivery
American University of Beirut Medical Center
 2006-10 PHASE2
NCT00536003 TERMINATED
Preterm Delivery; Morbidity; Perinatal Mortality
begoña Martinez de Tejada
 2006-07 PHASE3
NCT00809939 UNKNOWN
Pregnancy
Meir Medical Center
 2010-12 PHASE3
NCT01153581 COMPLETED
Orthostatic Intolerance
Yale University
 2006-02 PHASE2
NCT01741376 WITHDRAWN
Cocaine Dependence; Nicotine Dependence
University of Minnesota
 2012-11
NCT00632099 COMPLETED
Cocaine Dependence
New York State Psychiatric Institute
 2008-02 PHASE2; PHASE3
NCT01546454 COMPLETED
Coronary Heart Disease
Oregon Health and Science University
 2012-02
NCT00154180 UNKNOWN
Menopause; Arteriosclerosis
Kronos Longevity Research Institute
 2005-09 PHASE4
NCT01500863 COMPLETED
Ovarian Hyperstimulation Syndrome
IVI Madrid
 2011-11 PHASE4
NCT00646802 COMPLETED
Threatened Premature Labor
Hospital Clinic of Barcelona
 2008-06 PHASE4
NCT01391845 UNKNOWN
Infertility
Programa de Asistencia Reproductiva de Rosario
 2011-07
NCT02467673 COMPLETED
Menopausal Syndrome
University Potiguar
 2012-01 PHASE2
NCT00455962 COMPLETED
Premenopause; Healthy
Massachusetts General Hospital
 2005-01 PHASE1; PHASE2
NCT00577122 COMPLETED
Estrogen Receptor-negative Breast Cancer; Progesterone Receptor-negative Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer
Indiana University
 2007-07 PHASE2
NCT01123538 UNKNOWN
Pharmacogenomics; Systems Biology
University Hospital of North Norway
 2008-12 PHASE4
NCT01143207 COMPLETED
Contraception
FHI 360
 2010-05
NCT01465373 COMPLETED
Infertility
Fertility Centers of Illinois
 2010-02 PHASE4
NCT01810601 COMPLETED
Infertility
Ain Shams Maternity Hospital
 2009-09
NCT01057511 COMPLETED
Postmenopausal Endometrium
Peking Union Medical College Hospital
 2009-12 PHASE1; PHASE2
NCT00755963 COMPLETED
Hormone Replacement
Medical University of Vienna
 2009-05 PHASE4
NCT00828191 COMPLETED
In Vitro Fertilization
IBSA Institut Biochimique SA
 2008-12 PHASE3
NCT00579553 COMPLETED
Infant, Premature; Premature Birth
University of Oklahoma
 2006-10
NCT01056042 COMPLETED
Endometriosis
Prince of Songkla University
 2007-06 PHASE4
NCT00343265 COMPLETED
Preterm Birth
University of Calgary
 2006-06
NCT00088153 COMPLETED
Anorexia Nervosa
Massachusetts General Hospital
 2003-07 PHASE2; PHASE3
NCT00808132 COMPLETED
Menopause; Osteoporosis
Pfizer
 2009-01 PHASE3
NCT00739830 COMPLETED
Endometrial Cancer
Merck Sharp & Dohme LLC
 2008-08 PHASE2
NCT01191710 UNKNOWN
Pregnancy Outcome After In Vitro Fertilization (IVF)
Universitair Ziekenhuis Brussel
 2007-01 PHASE4
NCT00968409 COMPLETED
Breast Cancer
Washington University School of Medicine
 2007-01 PHASE1
NCT01019369 COMPLETED
Contraception
Carolyn L. Westhoff
 2010-03
NCT00928213 UNKNOWN
Preeclampsia
Ben-Gurion University of the Negev
 2009-08 PHASE2; PHASE3
NCT01220791 UNKNOWN
In Vitro Fertilization
Universitair Ziekenhuis Brussel
 2009-01 PHASE4
NCT01176175 COMPLETED
Infertility
Productos Científicos S. A. de C. V.
 2010-08 PHASE1
NCT00580333 COMPLETED
Breast Cancer
Massachusetts General Hospital
 2007-09 PHASE2
NCT00615550 COMPLETED
Preterm Delivery; Short Cervix; Short Uterine Cervical Length
Juniper Pharmaceuticals, Inc.
 2008-03 PHASE3
NCT01148420 COMPLETED
Dysfunctional Uterine Bleeding
Women's Health Care Clinic, Torrance, California
 2009-01 PHASE4
NCT00919919 UNKNOWN
Endometrial Hyperplasia; Endometrial Cancer
Rabin Medical Center
 2009-06 PHASE2
NCT00064025 COMPLETED
Endometrial Adenocarcinoma; Endometrial Adenosquamous Carcinoma; Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation; Recurrent Uterine Corpus Carcinoma; Stage I Uterine Corpus Cancer; Stage II Uterine Corpus Cancer; Stage III Uterine Corpus Cancer; Stage IV Uterine Corpus Cancer
Gynecologic Oncology Group
 2004-04 PHASE2
NCT01959464 COMPLETED
Infertility; Pregnancy
Wake Forest University Health Sciences
 2008-11 PHASE4
NCT00805935 COMPLETED
Polycystic Ovarian Syndrome; Infertility
Ferring Pharmaceuticals
 2009-01 PHASE4
NCT00029536 COMPLETED
Epilepsy
Beth Israel Deaconess Medical Center
 2000-10 PHASE3
NCT00331695 COMPLETED
Preterm Delivery
Assistance Publique - Hôpitaux de Paris
 2006-06 PHASE4
NCT00171340 COMPLETED
Bone Loss; Breast Cancer
Novartis Pharmaceuticals
 2003-05 PHASE3
NCT00830765 COMPLETED
Preterm Birth
University of Mississippi Medical Center
 2004-06
NCT00864214 COMPLETED
Menopause
Mayo Clinic
 2008-06 PHASE1
NCT00802360 COMPLETED
Infertility
Ferring Pharmaceuticals
 2008-12 PHASE4
NCT01010048 UNKNOWN
Urinary Calculus
Chongqing Medical University
 2009-10 PHASE4
NCT00163020 COMPLETED
Preterm Birth
Obstetrix Medical Group
 2004-11 PHASE2; PHASE3
NCT00702702 TERMINATED
Uterine Fibroids; Anemia
Repros Therapeutics Inc.
 2008-06 PHASE3
NCT00615251 COMPLETED
Infertility
Duramed Research
 2008-02 PHASE3
NCT00290251 COMPLETED
Leiomyoma
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2006-02 PHASE2
NCT00371345 COMPLETED
Breast Cancer; Metastasis
Bristol-Myers Squibb
 2006-12 PHASE2
NCT00696878 COMPLETED
In Vitro Fertilization
Organon and Co
 2006-09-26 PHASE3
NCT00676026 COMPLETED
Healthy
University of Pennsylvania
 2005-05
NCT00329914 COMPLETED
Preterm Delivery
Rigshospitalet, Denmark
 2006-06 PHASE2
NCT01180296 COMPLETED
Preterm Birth
Fetal Medicine Foundation
 2006-11 PHASE3
NCT00708539 UNKNOWN
IVF - Luteal Phase Support After Embryo Transfer
Nordica Fertility Clinic
 2006-04 PHASE4
NCT00775242 COMPLETED
Menopause
Centro A.F. de Estudios Tecnologicos, S.A.
 2007-04 PHASE2; PHASE3
NCT00958334 COMPLETED
Uterine Fibroids
Repros Therapeutics Inc.
 2006-09-07 PHASE2
NCT00271206 COMPLETED
Tobacco Use Disorder
Yale University
 2004-09 PHASE1
NCT00073528 COMPLETED
Breast Neoplasms
Novartis Pharmaceuticals
 2003-12-09 PHASE3
NCT00360490 COMPLETED
Menorrhagia
Bayer
 2006-07 PHASE3
NCT00828542 COMPLETED
Breastfeeding; Contraception
University of Sao Paulo
 2007-07
NCT00954811 UNKNOWN
Pregnancy; Pregnancy Loss
Universitair Ziekenhuis Brussel
 2005-09 PHASE4
NCT01011751 COMPLETED
Adenocarcinoma, Prostate
Takeda
 2004-04 PHASE3
NCT00543634 COMPLETED
Postmenopause
Wyeth is now a wholly owned subsidiary of Pfizer
 2007-10 PHASE1
NCT00191113 COMPLETED
Turner Syndrome
Eli Lilly and Company
 1989-02 PHASE3
NCT00206544 COMPLETED
Bipolar Disorder; Mania; Schizoaffective Disorder
The Alfred
 2004-01 PHASE2
NCT00000176 COMPLETED
Alzheimer Disease; Memory Disorders
National Institute on Aging (NIA)
 PHASE3
NCT00702845 COMPLETED
Infertility
Organon and Co
 2006-12-28 PHASE3
NCT01016665 COMPLETED
Breast Cancer
Federal University of São Paulo
 2005-04
NCT00044876 COMPLETED
Leiomyoma
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 2002-09-02 PHASE2
NCT00303615 TERMINATED
Metastatic Breast Cancer
Legacy Health System
 2005-06 PHASE2
NCT00480402 COMPLETED
Preterm Birth
Instituto Valenciano de Infertilidad, IVI VALENCIA
 2006-01 PHASE3
NCT00135902 COMPLETED
Preterm Birth
The George Washington University Biostatistics Center
 2005-02 PHASE3
NCT00882258 COMPLETED
Uterine Fibroids
Repros Therapeutics Inc.
 2006-03 PHASE2
NCT00455741 COMPLETED
Postmenopause; Aging
Massachusetts General Hospital
 2000-11 PHASE1; PHASE2
NCT00229697 COMPLETED
Breast Neoplasms
AstraZeneca
 2003-10 PHASE2
NCT00002920 COMPLETED
Breast Cancer; Endometrial Cancer
SWOG Cancer Research Network
 1997-03 PHASE3
NCT00694967 TERMINATED
Mid Trimester Cervical Shortening
Lehigh Valley Hospital
 2003-11
NCT00732693 COMPLETED
Premature Ovarian Failure
University of Edinburgh
 2002-02 PHASE4
NCT00099164 COMPLETED
Preterm Birth; Pregnancy; Multifetal
The George Washington University Biostatistics Center
 2004-04 PHASE3
NCT00305825 COMPLETED
Breast Cancer
University of California, San Francisco
 2004-08 PHASE2
NCT00117468 COMPLETED
Infertility
Duramed Research
 2005-06 PHASE2
NCT00003179 TERMINATED
Endometrial Cancer
Gynecologic Oncology Group
 1998-11 PHASE2
NCT00030914 COMPLETED
Hot Flashes
Alliance for Clinical Trials in Oncology
 2002-04 PHASE3
NCT00048646 COMPLETED
Traumatic Brain Injury
David Wright
 2002-05 PHASE1; PHASE2
NCT00745108 COMPLETED
Postmenopausal Women
Organon and Co
 2001-10-01 PHASE3
NCT00156650 COMPLETED
Contraception
University of Washington
 2004-12 PHASE1; PHASE2
NCT00134680 COMPLETED
Metastatic Breast Cancer
Duke University
 2000-01 PHASE2
NCT01069094 COMPLETED
Uterine Leiomyomata
Repros Therapeutics Inc.
 2004-07 PHASE1; PHASE2
NCT00006399 COMPLETED
Alzheimer Disease
National Center for Research Resources (NCRR)
 1999-09 PHASE2
NCT00026286 COMPLETED
Breast Cancer; Hot Flashes; Menopausal Symptoms
Eastern Cooperative Oncology Group
 2000-11-28 PHASE3
NCT03097120 COMPLETED
Heart Disease
Wake Forest University Health Sciences
 1995-01 PHASE3
NCT00041899 COMPLETED
Healthy
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 2002-05 PHASE1
NCT00000605 COMPLETED
Cardiovascular Diseases; Coronary Arteriosclerosis; Coronary Disease; Heart Diseases; Myocardial Ischemia; Postmenopause
National Heart, Lung, and Blood Institute (NHLBI)
 1996-08 PHASE3
NCT00416429 COMPLETED
Kidney Cancer
Centre Leon Berard
 PHASE3
NCT00422526 COMPLETED
Preterm Birth; Pregnancy Trimester, Second
King's College Hospital NHS Trust
 2003-09 PHASE3
NCT00674557 TERMINATED
Breast Cancer
Cancer Research UK
 2008-06 PHASE2
NCT00005108 COMPLETED
Atherosclerosis; Healthy; Vascular Disease
National Heart, Lung, and Blood Institute (NHLBI)
 2000-04 PHASE2
NCT00361075 COMPLETED
Menopause; Postmenopause; Premenopause; Cardiovascular Disease
Northwestern University
 1998-07 PHASE4
NCT00006133 COMPLETED
Systemic Lupus Erythematosus
National Center for Research Resources (NCRR)
 2000-06
NCT00319566 COMPLETED
Coronary Heart Disease
University of California, San Francisco
 1992-07 PHASE3
NCT00000601 COMPLETED
Angina, Unstable; Cardiovascular Diseases; Coronary Disease; Heart Diseases; Postmenopause
National Heart, Lung, and Blood Institute (NHLBI)
 1995-07 PHASE3
NCT00004650 COMPLETED
Osteoporosis
National Institute of Dental and Craniofacial Research (NIDCR)
 1993-08 PHASE3
NCT00026962 COMPLETED
Breast Cancer
National Cancer Institute (NCI)
 1999-09 PHASE2
NCT00329316 WITHDRAWN
Pregnancy; Premature Birth
The Baruch Padeh Medical Center, Poriya
NCT00377923 COMPLETED
Healthy
IBSA Institut Biochimique SA
 2005-08 PHASE1
NCT00006324 COMPLETED
HIV Infections
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 1999-12
NCT00016601 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 2001-06
NCT00044837 TERMINATED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE1
NCT00350480 COMPLETED
Uterine Hemorrhage; Menorrhagia
Kaiser Permanente
 2003-04
NCT00009659 COMPLETED
Postmenopause
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 2001-01 PHASE2
NCT00252811 WITHDRAWN
Breast Cancer
AstraZeneca
 2004-02 PHASE2
NCT00291369 COMPLETED
Metastatic Renal Cell Carcinoma
Centre Leon Berard
 1999-12 PHASE3
NCT00053339 WITHDRAWN
Stage IV Breast Cancer; Recurrent Breast Cancer
Alliance for Clinical Trials in Oncology
 PHASE3
NCT00210028 TERMINATED
Breast Neoplasms
Institut Claudius Regaud
 2003-08 PHASE2
NCT00294463 COMPLETED
Postmenopause; Osteoporosis
Erasmus Medical Center
 2003-02 PHASE4

(data from https://clinicaltrials.gov, updated on 2026-08-05)

Check the Progesterone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Progesterone functions as a potent agonist of the nuclear progesterone receptor (nPR) with a Kd of 1 nM and membrane progesterone receptors (mPRs), which induces receptor dimerization, gene transcriptional activation, and rapid non-genomic signaling cascades. These molecular events promote secretory transformation of the endometrium and regulate uterine motility, establishing essential physiological conditions required for luteal phase support during in vitro fertilization and the maintenance of pregnancy in clinical management of female infertility.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.