CAS No. 169590-42-5
Batch:
Purity:99.61
Chemical Structure
Check the
Celecoxib (SC-58635)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide | |
|---|---|---|
| CAS Number | 169590-42-5 | |
| Molecular Formula |
C17H14F3N3O2S |
|
| Molecular Weight (MW) | 381.37 | |
| SMILES | CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F | |
| InChIKey | RZEKVGVHFLEQIL-UHFFFAOYSA-N |
Celecoxib is a selective inhibitor of COX-2 (IC50 = with selectivity over COX-1 (IC50 =. By selectively targeting the COX-2 enzyme, celecoxib blocks the conversion of arachidonic acid to downstream prostaglandins, thereby inhibiting inflammatory prostaglandin production. This blockade of COX-2 signaling suppresses inflammatory responses and inhibits cell proliferation in COX-2-expressing cellular models. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(199.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 33 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(262.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 76 mg/mL |
| Water | Insoluble |
| DMSO |
76 mg/mL
(199.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 76 mg/mL |
| Water | Insoluble |
| DMSO |
76 mg/mL
(199.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 76 mg/mL |
| Water | Insoluble |
| DMSO |
76 mg/mL
(199.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 38 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Celecoxib (SC-58635) Mechanism of Action: COX-2 Inhibition in Cancer Cells Research
- Celecoxib (SC-58635) Clinical Trials
- Celecoxib (SC-58635) Working Concentration | Cell Culture | Treatment
- Celecoxib (SC-58635) Solubility in DMSO
- Celecoxib (SC-58635) Stock Solution
- Celecoxib (SC-58635) Storage
- Celecoxib (SC-58635) Stability
- Celecoxib (SC-58635) Combination Database
- Celecoxib (SC-58635) Molecular Weight
- Celecoxib (SC-58635) SMILES
- Celecoxib (SC-58635) Chemical Structure (2D and 3D)
- Celecoxib (SC-58635) IC50 for Cell-based and Cell-free Assays
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- Celecoxib (SC-58635) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.