Methotrexate: Mechanism of Action

Methotrexate MOA:Targeting Dihydrofolate Reductase/Folate Metabolism Pathway for Rheumatoid Arthritis and Autoimmune Diseases

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Methotrexate is a potent DHFR inhibitor. It affects NF-κB signaling pathways, by targeting DHFR, thereby inhibiting tumor growth.

Primary Applications and Mechanism of Action