Methotrexate is a potent DHFR inhibitor. It affects NF-κB signaling pathways, by targeting DHFR, thereby inhibiting tumor growth.
Comprehensive IC50 Values for Methotrexate Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.
Methotrexate is a potent DHFR inhibitor. It affects NF-κB signaling pathways, by targeting DHFR, thereby inhibiting tumor growth.