CAS No. 514814-49-4（free base)

Batch: Purity:99.47
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PMX 205 acetate Chemical Structure
Chemical Structure
Check the PMX 205 acetate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name acetic acid;N-[15-(cyclohexylmethyl)-9-[3-(diaminomethylideneamino)propyl]-12-(3H-indol-3-ylmethyl)-2,8,11,14,17-pentaoxo-1,7,10,13,16-pentazabicyclo[16.3.0]henicosan-3-yl]-3-phenylpropanamide
CAS Number 514814-49-4（free base)
Molecular Formula

C45H62N10O6
Molecular Weight (MW) 839.04
InChIKey JZNPQGVZXRXLDO-UHFFFAOYSA-N

Ordering Information

Biological Activity

PMX 205 acetate is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM. By selectively inhibiting C5aR signaling, it blocks C5a-mediated complement cascade activation and downstream pro-inflammatory pathways. This inhibition reduces inflammatory cell infiltration and pro-inflammatory cytokine secretion, demonstrating significant anti-inflammatory and neuroprotective activity in preclinical models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (119.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water 50 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.