CAS No. 1334237-71-6
Batch:
Purity:99.78
Chemical Structure
Check the
Etelcalcetide HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1334237-71-6 | |
|---|---|---|
| Molecular Formula |
C38H74ClN21O10S2 |
|
| Molecular Weight (MW) | 1084.71 | |
| SMILES | Cl.CC(NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CC(S)C(N)(S)C(O)=O)NC(C)=O)C(=O)NC(CCCN=C(N)N)C(N)=O |
Etelcalcetide HCl (AMG 416) is a synthetic peptide agonist of the calcium-sensing receptor (CaSR). Activation of CaSR on parathyroid cells leads to intracellular signal transduction that suppresses parathyroid hormone (PTH) secretion and regulates systemic calcium homeostasis. By allosterically modulating CaSR activity, etelcalcetide inhibits PTH synthesis and release, making it a key modulator of calcium-sensing signaling pathways. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(92.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.