SMILES:

CC(C)CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)C(N)CC2=CC=CC=C2)C(=O)NC(CCCCN)C(=O)N3CCC(N)(CC3)C(O)=O
Difelikefalin Chemical Structure
Chemical Structure
Check the Difelikefalin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-amino-1-[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid
CAS Number 1024828-77-0
Molecular Formula

C36H53N7O6
Molecular Weight (MW) 679.85
SMILES CC(C)CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)C(N)CC2=CC=CC=C2)C(=O)NC(CCCCN)C(=O)N3CCC(N)(CC3)C(O)=O
InChIKey FWMNVWWHGCHHJJ-SKKKGAJSSA-N

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (147.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.