CAS No. 934016-19-0

Batch: Purity:99.94
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Degarelix acetate Chemical Structure
Chemical Structure
Check the Degarelix acetate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide;acetic acid
CAS Number 934016-19-0
Molecular Formula

C82H103ClN18O16.C2H4O2
Molecular Weight (MW) 1632.26(free base)
InChIKey AUTFSFUMNFDPLH-KYMMNHPFSA-N

Biological Activity

Degarelix acetate is a potent and long-acting luteinizing hormone-releasing hormone (LHRH) receptor antagonist. By competitively blocking pituitary LHRH receptors, it inhibits the downstream release of gonadotropins, including luteinizing hormone and follicle-stimulating hormone. This blockade rapidly suppresses systemic testosterone secretion and androgen receptor pathway activation, resulting in significant inhibition of hormone-dependent prostate tumor growth in preclinical models. [1]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 33 mg/mL
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water 33 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Broqua P, et al. J Pharmacol Exp Ther. 2002;301(1):95-102.

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Note: Technical data last updated: Sep 1, 2026.