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Molecular Glues Chemicals

Cat.No. Product Name Information Product Use Citations Product Validations
S1029 CC-5013 (Lenalidomide) Lenalidomide is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.
Signal Transduct Target Ther, 2025, 10(1):29
Nat Commun, 2025, 16(1):3800
Cell Rep Med, 2025, S2666-3791(25)00102-8
Verified customer review of CC-5013 (Lenalidomide)
S1567 Pomalidomide (CC-4047) Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibiting the E3 ligase protein cereblon (CRBN). Pomalidomide promotes apoptosis and cell cycle arrest.
Nat Commun, 2025, 16(1):6631
Cell Rep Med, 2025, S2666-3791(25)00102-8
J Med Virol, 2025, 97(8):e70537
Verified customer review of Pomalidomide (CC-4047)
S1193 Thalidomide Thalidomide was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. This compound inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1.
Nat Genet, 2025, 57(10):2468-2481
Biomed Pharmacother, 2025, 184:117878
Nat Commun, 2024, 15(1):9195
Verified customer review of Thalidomide
E1413 DEG-77 DEG-77 is a cereblon-dependent degrader of IKZF2 and casein kinase 1α (CK1α). It blocks cell growth and delays leukemia progression in murine and human acute myeloid leukemia (AML) mouse models.